Purpose: To demonstrate the feasibility of three-dimensional thick-partition, contrast-enhanced, catheter-directed coronary artery magnetic resonance angiography (MRA) and test the hypothesis that three-dimensional imaging improves coronary artery background contrast-to-noise ratio (CNR) compared to two-dimensional imaging. Materials and Methods: Catheters were advanced into the coronary arteries of swine (N = 6) under MR guidance. Three-dimensional coronary MRA was performed after intracoronary injection of a small dose of contrast media using magnetization-prepared steady-state free precession (SSFP) with two thick partitions. For comparison, two magnetization-prepared two-dimensional SSFP scans were also performed, one with no signal averaging and one with two signal averages. All sequences had the same coverage and in-plane spatial resolution. Results: The coronary artery was successfully catheterized in all (6/6) animals. CNR for three-dimensional imaging was 11.1 ± 1.2 for proximal arterial segments and 4.3 ± 0.4 for distal segments. Without averaging, two-dimensional imaging CNRs for proximal and distal segments were 5.0 ± 0.7 and 1.2 ± 0.2, respectively. With averaging, two-dimensional imaging CNRs for proximal and distal segments were 9.4 ± 1.5 and 2.9 ± 0.4, respectively. Three-dimensional imaging showed a statistically significant increase in CNR over all two-dimensional imaging for both proximal and distal segments (P < 0.05). Conclusion: Three-dimensional thick-partition, contrast-enhanced, catheter-directed coronary MRA is feasible and improves CNR over two-dimensional projection imaging.
- Coronary vessels
- Interventional MRI
- MR angiography
- Magnetic resonance (MR)
- Steady-state free precession (SSFP)
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging