Three-dimensional photoacoustic imaging of subcutaneous microvasculature in vivo

Hao F. Zhang; Meng Lin Li; Konstantin Maslov; George Stoica; Lihong V. Wang

doi:10.1117/12.645138

Three-dimensional photoacoustic imaging of subcutaneous microvasculature in vivo

Hao F. Zhang^*, Meng Lin Li, Konstantin Maslov, George Stoica, Lihong V. Wang

^*Corresponding author for this work

Biomedical Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

1 Scopus citations

Abstract

Three-dimensional photoacoustic imaging of subcutaneous microvasculature in small animals is realized in vivo using photoacoustic microscopy. Previously, degraded lateral resolution in the out-of-focus region made three-dimensional visualization impractical. With the help of a virtual-detector synthetic aperture focusing technique, depth-independent lateral resolution is achieved. Therefore, volumetric imaging of the vessels is realized with a lateral resolution of 45 μm and an axial resolution of 15 μm. Detailed structural information, such as vessel depth and spatial orientation, are revealed with new clarity.

Original language	English (US)
Title of host publication	Photons Plus Ultrasound
Subtitle of host publication	Imaging and Sensing 2006 - The Seventh Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics
Publisher	SPIE
ISBN (Print)	0819461288, 9780819461285
DOIs	https://doi.org/10.1117/12.645138
State	Published - Feb 9 2006
Event	7th Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics - Photons Plus Ultrasound: Imaging and Sensing 2006 - San Jose, CA, United States Duration: Jan 22 2006 → Jan 26 2006

Publication series

Name	Proceedings of SPIE - The International Society for Optical Engineering
Volume	6086
ISSN (Print)	0277-786X

Other

Other	7th Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics - Photons Plus Ultrasound: Imaging and Sensing 2006
Country/Territory	United States
City	San Jose, CA
Period	1/22/06 → 1/26/06

Keywords

Microscopy
Microvasculature
Photoacoustic

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Condensed Matter Physics
Computer Science Applications
Applied Mathematics
Electrical and Electronic Engineering

Access to Document

10.1117/12.645138

Cite this

Zhang, H. F., Li, M. L., Maslov, K., Stoica, G., & Wang, L. V. (2006). Three-dimensional photoacoustic imaging of subcutaneous microvasculature in vivo. In Photons Plus Ultrasound: Imaging and Sensing 2006 - The Seventh Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics Article 60861E (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 6086). SPIE. https://doi.org/10.1117/12.645138

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title = "Three-dimensional photoacoustic imaging of subcutaneous microvasculature in vivo",

abstract = "Three-dimensional photoacoustic imaging of subcutaneous microvasculature in small animals is realized in vivo using photoacoustic microscopy. Previously, degraded lateral resolution in the out-of-focus region made three-dimensional visualization impractical. With the help of a virtual-detector synthetic aperture focusing technique, depth-independent lateral resolution is achieved. Therefore, volumetric imaging of the vessels is realized with a lateral resolution of 45 μm and an axial resolution of 15 μm. Detailed structural information, such as vessel depth and spatial orientation, are revealed with new clarity.",

keywords = "Microscopy, Microvasculature, Photoacoustic",

author = "Zhang, {Hao F.} and Li, {Meng Lin} and Konstantin Maslov and George Stoica and Wang, {Lihong V.}",

year = "2006",

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language = "English (US)",

isbn = "0819461288",

series = "Proceedings of SPIE - The International Society for Optical Engineering",

publisher = "SPIE",

booktitle = "Photons Plus Ultrasound",

note = "7th Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics - Photons Plus Ultrasound: Imaging and Sensing 2006 ; Conference date: 22-01-2006 Through 26-01-2006",

}

Zhang, HF, Li, ML, Maslov, K, Stoica, G & Wang, LV 2006, Three-dimensional photoacoustic imaging of subcutaneous microvasculature in vivo. in Photons Plus Ultrasound: Imaging and Sensing 2006 - The Seventh Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics., 60861E, Proceedings of SPIE - The International Society for Optical Engineering, vol. 6086, SPIE, 7th Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics - Photons Plus Ultrasound: Imaging and Sensing 2006, San Jose, CA, United States, 1/22/06. https://doi.org/10.1117/12.645138

Three-dimensional photoacoustic imaging of subcutaneous microvasculature in vivo. / Zhang, Hao F.; Li, Meng Lin; Maslov, Konstantin et al.
Photons Plus Ultrasound: Imaging and Sensing 2006 - The Seventh Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics. SPIE, 2006. 60861E (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 6086).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

TY - GEN

T1 - Three-dimensional photoacoustic imaging of subcutaneous microvasculature in vivo

AU - Zhang, Hao F.

AU - Li, Meng Lin

AU - Maslov, Konstantin

AU - Stoica, George

AU - Wang, Lihong V.

PY - 2006/2/9

Y1 - 2006/2/9

N2 - Three-dimensional photoacoustic imaging of subcutaneous microvasculature in small animals is realized in vivo using photoacoustic microscopy. Previously, degraded lateral resolution in the out-of-focus region made three-dimensional visualization impractical. With the help of a virtual-detector synthetic aperture focusing technique, depth-independent lateral resolution is achieved. Therefore, volumetric imaging of the vessels is realized with a lateral resolution of 45 μm and an axial resolution of 15 μm. Detailed structural information, such as vessel depth and spatial orientation, are revealed with new clarity.

AB - Three-dimensional photoacoustic imaging of subcutaneous microvasculature in small animals is realized in vivo using photoacoustic microscopy. Previously, degraded lateral resolution in the out-of-focus region made three-dimensional visualization impractical. With the help of a virtual-detector synthetic aperture focusing technique, depth-independent lateral resolution is achieved. Therefore, volumetric imaging of the vessels is realized with a lateral resolution of 45 μm and an axial resolution of 15 μm. Detailed structural information, such as vessel depth and spatial orientation, are revealed with new clarity.

KW - Microscopy

KW - Microvasculature

KW - Photoacoustic

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M3 - Conference contribution

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SN - 9780819461285

T3 - Proceedings of SPIE - The International Society for Optical Engineering

BT - Photons Plus Ultrasound

PB - SPIE

T2 - 7th Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics - Photons Plus Ultrasound: Imaging and Sensing 2006

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Zhang HF, Li ML, Maslov K, Stoica G, Wang LV. Three-dimensional photoacoustic imaging of subcutaneous microvasculature in vivo. In Photons Plus Ultrasound: Imaging and Sensing 2006 - The Seventh Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics. SPIE. 2006. 60861E. (Proceedings of SPIE - The International Society for Optical Engineering). doi: 10.1117/12.645138

Three-dimensional photoacoustic imaging of subcutaneous microvasculature in vivo

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