Three-directional acceleration phase mapping of myocardial function

Felix Staehle, Bernd A. Jung, Simon Bauer, Jochen Leupold, Jelena Bock, Ramona Lorenz, Daniela Föll, Michael Markl*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

An optimized acceleration encoded phase contrast method termed "acceleration phase mapping" for the assessment of regional myocardial function is presented. Based on an efficient gradient waveform design using two-sided encoding for in vivo three-directional acceleration mapping, echo and repetition times TE = 12-14 ms and TR = 15-17 ms for low accelerations sensitivity aenc = 5-8 m/s2 were achieved. In addition to phantom validation, the technique was applied in a study with 10 healthy volunteers at 1.5T and 3T to evaluate its feasibility to assess regional myocardial acceleration at 1.5T and 3T. Results of the acceleration measurements were compared with the temporal derivative of myocardial velocities from three-directional velocity encoded standard phase contrast MRI in the same volunteers. The feasibility to assess myocardial acceleration along the radial, circumferential, and longitudinal direction of the left ventricle was demonstrated. Despite improved signal-to-noise-ratio at 3T (34% increase compared with 1.5T), image quality with respect to susceptibility artifacts was better 1.5T compared with 3T. Analysis of global and regional left ventricular acceleration showed characteristic patterns of systolic and diastolic acceleration and deceleration. Comparisons of directly measured and derived myocardial acceleration dynamics over the cardiac cycle revealed good correlation (r = 0.45-0.68, P < 0.01) between both methods. Magn Reson Med, 2011.

Original languageEnglish (US)
Pages (from-to)1335-1345
Number of pages11
JournalMagnetic resonance in medicine
Volume65
Issue number5
DOIs
StatePublished - May 2011

Keywords

  • acceleration
  • cardiac
  • heart
  • myocardium
  • phase contrast MRI

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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