Three-layer composite magnetic nanoparticle probes for DNA

Savka I. Stoeva, Fengwei Huo, Jae Seung Lee, Chad A. Mirkin*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

288 Scopus citations


A method for synthesizing composite nanoparticles with a gold shell, an Fe3O4 inner shell, and a silica core has been developed. The approach utilizes positively charged amino-modified SiO2 particles as templates for the assembly of negatively charged 15 nm superparamagnetic water-soluble Fe3O4 nanoparticles. The SiO2-Fe3O4 particles electrostatically attract 1-3 nm Au nanoparticle seeds that act in a subsequent step as nucleation sites for the formation of a continuous gold shell around the SiO2-Fe3O4 particles upon HAuCl4 reduction. The three-layer magnetic nanoparticles, when functionalized with oligonucleotides, exhibit the surface chemistry, optical properties, and cooperative DNA binding properties of gold nanoparticle probes, but the magnetic properties of the Fe3O4 inner shell.

Original languageEnglish (US)
Pages (from-to)15362-15363
Number of pages2
JournalJournal of the American Chemical Society
Issue number44
StatePublished - Nov 9 2005

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry


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