Three putative 5-HT1A agonists act as 5-HT antagonists in frog sensory neurons

William Marszalec, Edmund G. Anderson*

*Corresponding author for this work

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

The putative 5-HT1A agonists 8-hydroxy-dipropylaminotetralin (DPAT), buspirone and p-aminophenylethyl-m-trifluoromethylphenyl piperazine (PAPP) were tested for their ability to narrow the action potentials of bullfrog sensory neurons, a serotonergic response observed to be blocked by the 5-HT1A antagonists spiperone and spiroxitrine. Given alone, DPAT, buspirone, and PAPP were ineffective 5-HT agonists. When applied concomitantly with 5-HT, however, they significantly antagonized the original response. Thus, in some systems these putative 5-HT1A agonists function as antagonists.

Original languageEnglish (US)
Pages (from-to)325-328
Number of pages4
JournalEuropean Journal of Pharmacology
Volume154
Issue number3
DOIs
StatePublished - Sep 23 1988

Keywords

  • (Sensory neuron)
  • 8-OH-DPAT (8-hydroxy-2-(di-n-propylamino)tetralin)
  • Buspirone
  • PAPP (p-aminophenylethyl-m-trifluoromethylphenylpiperazine)
  • Serotonin (5-HT)

ASJC Scopus subject areas

  • Pharmacology

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