The putative 5-HT1A agonists 8-hydroxy-dipropylaminotetralin (DPAT), buspirone and p-aminophenylethyl-m-trifluoromethylphenyl piperazine (PAPP) were tested for their ability to narrow the action potentials of bullfrog sensory neurons, a serotonergic response observed to be blocked by the 5-HT1A antagonists spiperone and spiroxitrine. Given alone, DPAT, buspirone, and PAPP were ineffective 5-HT agonists. When applied concomitantly with 5-HT, however, they significantly antagonized the original response. Thus, in some systems these putative 5-HT1A agonists function as antagonists.
- (Sensory neuron)
- 8-OH-DPAT (8-hydroxy-2-(di-n-propylamino)tetralin)
- PAPP (p-aminophenylethyl-m-trifluoromethylphenylpiperazine)
- Serotonin (5-HT)
ASJC Scopus subject areas