TY - JOUR
T1 - Thrombocytopenia in Chronic Liver Disease
T2 - New Management Strategies
AU - Nilles, Kathy M.
AU - Flamm, Steven L.
PY - 2020/8
Y1 - 2020/8
N2 - Thrombocytopenia is common in advanced liver disease, and such patients frequently need invasive procedures. Numerous mechanisms for thrombocytopenia exist, including splenic sequestration and reduction of levels of the platelet growth factor thrombopoietin. Traditionally, platelet transfusions have been used to increase platelet counts before elective procedures, usually to a threshold of greater than or equal to 50,000/μL, but levels vary by provider, procedure, and specific patient. Recently, the thrombopoietin receptor agonists avatrombopag and lusutrombopag were studied and found efficacious for increasing platelet count in the outpatient setting for select patients with advanced liver disease who need a procedure.
AB - Thrombocytopenia is common in advanced liver disease, and such patients frequently need invasive procedures. Numerous mechanisms for thrombocytopenia exist, including splenic sequestration and reduction of levels of the platelet growth factor thrombopoietin. Traditionally, platelet transfusions have been used to increase platelet counts before elective procedures, usually to a threshold of greater than or equal to 50,000/μL, but levels vary by provider, procedure, and specific patient. Recently, the thrombopoietin receptor agonists avatrombopag and lusutrombopag were studied and found efficacious for increasing platelet count in the outpatient setting for select patients with advanced liver disease who need a procedure.
KW - Advanced liver disease
KW - Cirrhosis
KW - Invasive procedures
KW - Low platelets
KW - TPO receptor agonists
KW - Thrombocytopenia
KW - Thrombopoietin
UR - http://www.scopus.com/inward/record.url?scp=85085617515&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85085617515&partnerID=8YFLogxK
U2 - 10.1016/j.cld.2020.04.009
DO - 10.1016/j.cld.2020.04.009
M3 - Review article
C2 - 32620282
AN - SCOPUS:85085617515
VL - 24
SP - 437
EP - 451
JO - Clinics in Liver Disease
JF - Clinics in Liver Disease
SN - 1089-3261
IS - 3
ER -