Thrombocytosis and Thrombosis: Is There Really a Correlation?

Carlos Galvez, Brady L. Stein*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

Purpose of Review: Thrombocytosis is common to all myeloproliferative neoplasms (MPN), including essential thrombocythemia (ET), polycythemia vera (PV), and myelofibrosis. Despite the traditionally held belief amongst many clinicians that thrombocytosis correlates with thrombosis risk, there is little evidence in the literature to support that claim. Herein we critically analyze the literature to better understand the relationship between thrombocytosis and risk of thrombosis in MPN. Recent Findings: Both retrospective and prospective studies argue against associations between thrombocytosis and risk of thrombosis in patients with ET and PV. Rather, most studies suggest that the presence of extreme thrombocytosis is instead associated with an increased risk of hemorrhagic events, a paradoxical phenomenon with important clinical implications. Summary: Thrombosis risk has a multifactorial set of etiologies in MPNs. While qualitative abnormalities of the platelets may contribute, associations between platelet quantity and thrombosis risk are weak in MPN patients.

Original languageEnglish (US)
Pages (from-to)261-267
Number of pages7
JournalCurrent Hematologic Malignancy Reports
Volume15
Issue number4
DOIs
StatePublished - Aug 1 2020

Keywords

  • Essential thrombocythemia
  • Myeloproliferative neoplasms
  • Polycythemia vera
  • Thrombocytosis
  • Thrombosis

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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