Thromboembolic complications associated with L‐asparaginase therapy. Etiologic role of low antithrombin III and plasminogen levels and therapeutic correction by fresh frozen plasma

Omer Kucuk*, Hau C. Kwaan, William Gunnar, Richard M. Vazquez

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

80 Scopus citations

Abstract

A case of an 18‐year‐old woman with acute lymphoblastic leukemia who developed L‐asparaginase‐associated stroke and subclavian vein thrombosis is presented. The latter was also associated with a Hickman central venous catheter. Thrombotic complications occurred when plasma levels of plasminogen and antithrombin III were still markedly reduced as a result of L‐asparaginase therapy, although the fibrinogen had recovered from its lower levels. The stroke was treated with fresh frozen plasma and the subclavian vein thrombosis was treated with streptokinase and fresh frozen plasma. L‐asparaginase and Hickman‐associated coagulopathy is reviewed and the treatment is discussed.

Original languageEnglish (US)
Pages (from-to)702-706
Number of pages5
JournalCancer
Volume55
Issue number4
DOIs
StatePublished - Feb 15 1985

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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