Alan Peaceman*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter


Thromboembolism remains a leading cause of obstetric morbidity and mortality in the United States. This chapter discusses the pathophysiology, diagnosis, treatment, prevention and special considerations of acute thromboembolism. The diagnosis of deep venous thrombosis (DVT) is often difficult to make clinically, especially in pregnancy. The presenting signs and symptoms of pulmonary embolism (PE) include shortness of breath, chest pain, tachypnea, tachycardia, and decreased oxygen saturation by pulse oxymeter. Acute DVT or PE should be treated with full anticoagulation using either intravenous heparin or subcutaneous low-molecular-weight heparin, and it is important to achieve therapeutic doses very early to prevent extension of clot. The use of anticoagulation to prevent thromboembolism is more controversial. Traditionally, chemoprophylaxis has been recommended to pregnant patients with a history of thrombosis with the idea that pregnancy significantly increases the risk of recurrence.

Original languageEnglish (US)
Title of host publicationProtocols for High-Risk Pregnancies
Subtitle of host publicationAn Evidence-Based Approach: Sixth Edition
Number of pages7
ISBN (Electronic)9781119001256
ISBN (Print)9781119000877
StatePublished - Jan 1 2015


  • Acute thromboembolism
  • Anticoagulation
  • Chemoprophylaxis
  • Deep venous thrombosis (DVT)
  • Pulmonary embolism (PE)

ASJC Scopus subject areas

  • Medicine(all)


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