Thrombosis in the philadelphia chromosome-negative myeloproliferative neoplasms

Kamya Sankar, Brady Lee Stein, Raajit K. Rampal*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations


The myeloproliferative neoplasms (MPNs) are clonal stem cell-derived diseases. This chapter focuses on the subcategory of Philadelphia (Ph) chromosome-negative classical MPNs, polycythemia vera (PV), essential thrombocythemia (ET), primary myelofibrosis (PMF). These MPNs are associated with both microvascular and macrovascular thrombosis, which may occur in the venous and arterial circulation. Erythrocytosis, leukocytosis, and increased JAK2V617F allele burden are known to be risk factors. In this chapter, we review the thrombotic and hemostatic manifestations of the Philadelphia (Ph) chromosome-negative classical MPNs, including the clinical manifestations, the pathophysiology, as well as management.

Original languageEnglish (US)
Title of host publicationCancer Treatment and Research
PublisherSpringer International Publishing
Number of pages20
StatePublished - Jan 1 2019

Publication series

NameCancer Treatment and Research
ISSN (Print)0927-3042
ISSN (Electronic)2509-8497


  • Essential thrombocythemia
  • JAK2V617F
  • Macrovascular thrombosis
  • Microvascular thrombosis
  • Myelofibrosis
  • Myeloproliferative neoplasms
  • Polycythemia vera

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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