Thrombosis in the philadelphia chromosome-negative myeloproliferative neoplasms

Kamya Sankar; Brady L. Stein; Raajit K. Rampal

doi:10.1007/978-3-030-20315-3_11

Thrombosis in the philadelphia chromosome-negative myeloproliferative neoplasms

Kamya Sankar, Brady L. Stein, Raajit K. Rampal^*

^*Corresponding author for this work

Medicine, Hematology Oncology Division

Research output: Chapter in Book/Report/Conference proceeding › Chapter

20 Scopus citations

Abstract

The myeloproliferative neoplasms (MPNs) are clonal stem cell-derived diseases. This chapter focuses on the subcategory of Philadelphia (Ph) chromosome-negative classical MPNs, polycythemia vera (PV), essential thrombocythemia (ET), primary myelofibrosis (PMF). These MPNs are associated with both microvascular and macrovascular thrombosis, which may occur in the venous and arterial circulation. Erythrocytosis, leukocytosis, and increased JAK2V617F allele burden are known to be risk factors. In this chapter, we review the thrombotic and hemostatic manifestations of the Philadelphia (Ph) chromosome-negative classical MPNs, including the clinical manifestations, the pathophysiology, as well as management.

Original language	English (US)
Title of host publication	Cancer Treatment and Research
Publisher	Springer International Publishing
Pages	159-178
Number of pages	20
DOIs	https://doi.org/10.1007/978-3-030-20315-3_11
State	Published - 2019

Publication series

Name	Cancer Treatment and Research
Volume	179
ISSN (Print)	0927-3042
ISSN (Electronic)	2509-8497

Keywords

Essential thrombocythemia
JAK2V617F
Macrovascular thrombosis
Microvascular thrombosis
Myelofibrosis
Myeloproliferative neoplasms
Polycythemia vera

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/978-3-030-20315-3_11

Cite this

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title = "Thrombosis in the philadelphia chromosome-negative myeloproliferative neoplasms",

abstract = "The myeloproliferative neoplasms (MPNs) are clonal stem cell-derived diseases. This chapter focuses on the subcategory of Philadelphia (Ph) chromosome-negative classical MPNs, polycythemia vera (PV), essential thrombocythemia (ET), primary myelofibrosis (PMF). These MPNs are associated with both microvascular and macrovascular thrombosis, which may occur in the venous and arterial circulation. Erythrocytosis, leukocytosis, and increased JAK2V617F allele burden are known to be risk factors. In this chapter, we review the thrombotic and hemostatic manifestations of the Philadelphia (Ph) chromosome-negative classical MPNs, including the clinical manifestations, the pathophysiology, as well as management.",

keywords = "Essential thrombocythemia, JAK2V617F, Macrovascular thrombosis, Microvascular thrombosis, Myelofibrosis, Myeloproliferative neoplasms, Polycythemia vera",

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year = "2019",

doi = "10.1007/978-3-030-20315-3_11",

language = "English (US)",

series = "Cancer Treatment and Research",

publisher = "Springer International Publishing",

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T1 - Thrombosis in the philadelphia chromosome-negative myeloproliferative neoplasms

AU - Sankar, Kamya

AU - Stein, Brady L.

AU - Rampal, Raajit K.

PY - 2019

Y1 - 2019

N2 - The myeloproliferative neoplasms (MPNs) are clonal stem cell-derived diseases. This chapter focuses on the subcategory of Philadelphia (Ph) chromosome-negative classical MPNs, polycythemia vera (PV), essential thrombocythemia (ET), primary myelofibrosis (PMF). These MPNs are associated with both microvascular and macrovascular thrombosis, which may occur in the venous and arterial circulation. Erythrocytosis, leukocytosis, and increased JAK2V617F allele burden are known to be risk factors. In this chapter, we review the thrombotic and hemostatic manifestations of the Philadelphia (Ph) chromosome-negative classical MPNs, including the clinical manifestations, the pathophysiology, as well as management.

AB - The myeloproliferative neoplasms (MPNs) are clonal stem cell-derived diseases. This chapter focuses on the subcategory of Philadelphia (Ph) chromosome-negative classical MPNs, polycythemia vera (PV), essential thrombocythemia (ET), primary myelofibrosis (PMF). These MPNs are associated with both microvascular and macrovascular thrombosis, which may occur in the venous and arterial circulation. Erythrocytosis, leukocytosis, and increased JAK2V617F allele burden are known to be risk factors. In this chapter, we review the thrombotic and hemostatic manifestations of the Philadelphia (Ph) chromosome-negative classical MPNs, including the clinical manifestations, the pathophysiology, as well as management.

KW - Essential thrombocythemia

KW - JAK2V617F

KW - Macrovascular thrombosis

KW - Microvascular thrombosis

KW - Myelofibrosis

KW - Myeloproliferative neoplasms

KW - Polycythemia vera

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AN - SCOPUS:85069500262

T3 - Cancer Treatment and Research

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BT - Cancer Treatment and Research

PB - Springer International Publishing

ER -

Thrombosis in the philadelphia chromosome-negative myeloproliferative neoplasms

Abstract

Publication series

Keywords

ASJC Scopus subject areas

UN SDGs

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