Thrombosis in the philadelphia chromosome-negative myeloproliferative neoplasms

Kamya Sankar, Brady Lee Stein, Raajit K. Rampal*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The myeloproliferative neoplasms (MPNs) are clonal stem cell-derived diseases. This chapter focuses on the subcategory of Philadelphia (Ph) chromosome-negative classical MPNs, polycythemia vera (PV), essential thrombocythemia (ET), primary myelofibrosis (PMF). These MPNs are associated with both microvascular and macrovascular thrombosis, which may occur in the venous and arterial circulation. Erythrocytosis, leukocytosis, and increased JAK2V617F allele burden are known to be risk factors. In this chapter, we review the thrombotic and hemostatic manifestations of the Philadelphia (Ph) chromosome-negative classical MPNs, including the clinical manifestations, the pathophysiology, as well as management.

Original languageEnglish (US)
Title of host publicationCancer Treatment and Research
PublisherSpringer International Publishing
Pages159-178
Number of pages20
DOIs
StatePublished - Jan 1 2019

Publication series

NameCancer Treatment and Research
Volume179
ISSN (Print)0927-3042

Fingerprint

Philadelphia Chromosome
Thrombosis
Neoplasms
Essential Thrombocythemia
Polycythemia Vera
Polycythemia
Primary Myelofibrosis
Leukocytosis
Hemostatics
Stem Cells
Alleles

Keywords

  • Essential thrombocythemia
  • JAK2V617F
  • Macrovascular thrombosis
  • Microvascular thrombosis
  • Myelofibrosis
  • Myeloproliferative neoplasms
  • Polycythemia vera

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Sankar, K., Stein, B. L., & Rampal, R. K. (2019). Thrombosis in the philadelphia chromosome-negative myeloproliferative neoplasms. In Cancer Treatment and Research (pp. 159-178). (Cancer Treatment and Research; Vol. 179). Springer International Publishing. https://doi.org/10.1007/978-3-030-20315-3_11
Sankar, Kamya ; Stein, Brady Lee ; Rampal, Raajit K. / Thrombosis in the philadelphia chromosome-negative myeloproliferative neoplasms. Cancer Treatment and Research. Springer International Publishing, 2019. pp. 159-178 (Cancer Treatment and Research).
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Sankar, K, Stein, BL & Rampal, RK 2019, Thrombosis in the philadelphia chromosome-negative myeloproliferative neoplasms. in Cancer Treatment and Research. Cancer Treatment and Research, vol. 179, Springer International Publishing, pp. 159-178. https://doi.org/10.1007/978-3-030-20315-3_11

Thrombosis in the philadelphia chromosome-negative myeloproliferative neoplasms. / Sankar, Kamya; Stein, Brady Lee; Rampal, Raajit K.

Cancer Treatment and Research. Springer International Publishing, 2019. p. 159-178 (Cancer Treatment and Research; Vol. 179).

Research output: Chapter in Book/Report/Conference proceedingChapter

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Sankar K, Stein BL, Rampal RK. Thrombosis in the philadelphia chromosome-negative myeloproliferative neoplasms. In Cancer Treatment and Research. Springer International Publishing. 2019. p. 159-178. (Cancer Treatment and Research). https://doi.org/10.1007/978-3-030-20315-3_11