Thrombospondins and angiogenesis

Nathan V. Lee, M. Luisa Iruela-Arispe

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Thrombospondins (TSPs) include a multimeric family of secreted glycoproteins broadly expressed by several cells and tissues. They have been shown to support cell attachment through interactions with multiple cell-adhesion receptors, bind to other extracellular matrix proteins, and regulate cell shape, adhesion and migration. At the tissue level, TSPs have been implicated in the regulation of several complex processes, including angiogenesis and wound healing. More recently, some TSPs have been associated with genetic predisposition for myocardial infarction and vascular disease through genome-wide scans and SNP studies. In this chapter, we summarize the current information on the biology of TSPs, focusing more directly on the angioregulatory roles of TSP1 and-2. We will further discuss the most recent genetic and biochemical advances and their therapeutic exploration.

Original languageEnglish (US)
Title of host publicationTumor Angiogenesis
Subtitle of host publicationBasic Mechanisms and Cancer Therapy
PublisherSpringer Berlin Heidelberg
Pages233-245
Number of pages13
ISBN (Print)9783540331766
DOIs
StatePublished - Dec 1 2008

ASJC Scopus subject areas

  • Medicine(all)

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