Thrombotic effects of angiotensin

D. E. Vaughan*

*Corresponding author for this work

Research output: Contribution to journalShort survey

2 Citations (Scopus)

Abstract

Reduced risk of myocardial infarction (MI) mortality with angiotensin-converting enzyme (ACE) inhibition suggests a link between the renin-angiotensin-system (RAS) and fibrinolytic function. Excessive endothelial production of plasminogen activator inhibitor type 1 (PAI-1) and deficient endothelial secretion of tissue-type plasminogen activator (t-PA) are associated with thrombosis and ischemic events, such as stroke, atherosclerosis, and MI. Angiotensin II (A-II) regulates PAI-1 production. Suppression of A-II formation by ACE inhibitors likely has a positive effect on Fibrinolytic balance by reducing the production of PAI-1. ACE inhibition also enhances bradykinin levels, which, in turn, increases t-PA secretion and further reduces thrombotic tendency.

Original languageEnglish (US)
Pages (from-to)44-49
Number of pages6
JournalJournal of Myocardial Ischemia
Volume7
Issue numberSUPPL. 1
StatePublished - Jan 1 1995

Fingerprint

Plasminogen Activator Inhibitor 1
Angiotensins
Peptidyl-Dipeptidase A
Angiotensin II
Myocardial Infarction
Plasminogen Inactivators
Plasminogen Activators
Bradykinin
Tissue Plasminogen Activator
Renin-Angiotensin System
Angiotensin-Converting Enzyme Inhibitors
Endothelium
Atherosclerosis
Thrombosis
Stroke
Mortality

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

@article{fdec08f5cc6c45878d4a919b213a018b,
title = "Thrombotic effects of angiotensin",
abstract = "Reduced risk of myocardial infarction (MI) mortality with angiotensin-converting enzyme (ACE) inhibition suggests a link between the renin-angiotensin-system (RAS) and fibrinolytic function. Excessive endothelial production of plasminogen activator inhibitor type 1 (PAI-1) and deficient endothelial secretion of tissue-type plasminogen activator (t-PA) are associated with thrombosis and ischemic events, such as stroke, atherosclerosis, and MI. Angiotensin II (A-II) regulates PAI-1 production. Suppression of A-II formation by ACE inhibitors likely has a positive effect on Fibrinolytic balance by reducing the production of PAI-1. ACE inhibition also enhances bradykinin levels, which, in turn, increases t-PA secretion and further reduces thrombotic tendency.",
author = "Vaughan, {D. E.}",
year = "1995",
month = "1",
day = "1",
language = "English (US)",
volume = "7",
pages = "44--49",
journal = "Journal of Myocardial Ischemia",
issn = "1045-7984",
publisher = "PRR Inc.",
number = "SUPPL. 1",

}

Thrombotic effects of angiotensin. / Vaughan, D. E.

In: Journal of Myocardial Ischemia, Vol. 7, No. SUPPL. 1, 01.01.1995, p. 44-49.

Research output: Contribution to journalShort survey

TY - JOUR

T1 - Thrombotic effects of angiotensin

AU - Vaughan, D. E.

PY - 1995/1/1

Y1 - 1995/1/1

N2 - Reduced risk of myocardial infarction (MI) mortality with angiotensin-converting enzyme (ACE) inhibition suggests a link between the renin-angiotensin-system (RAS) and fibrinolytic function. Excessive endothelial production of plasminogen activator inhibitor type 1 (PAI-1) and deficient endothelial secretion of tissue-type plasminogen activator (t-PA) are associated with thrombosis and ischemic events, such as stroke, atherosclerosis, and MI. Angiotensin II (A-II) regulates PAI-1 production. Suppression of A-II formation by ACE inhibitors likely has a positive effect on Fibrinolytic balance by reducing the production of PAI-1. ACE inhibition also enhances bradykinin levels, which, in turn, increases t-PA secretion and further reduces thrombotic tendency.

AB - Reduced risk of myocardial infarction (MI) mortality with angiotensin-converting enzyme (ACE) inhibition suggests a link between the renin-angiotensin-system (RAS) and fibrinolytic function. Excessive endothelial production of plasminogen activator inhibitor type 1 (PAI-1) and deficient endothelial secretion of tissue-type plasminogen activator (t-PA) are associated with thrombosis and ischemic events, such as stroke, atherosclerosis, and MI. Angiotensin II (A-II) regulates PAI-1 production. Suppression of A-II formation by ACE inhibitors likely has a positive effect on Fibrinolytic balance by reducing the production of PAI-1. ACE inhibition also enhances bradykinin levels, which, in turn, increases t-PA secretion and further reduces thrombotic tendency.

UR - http://www.scopus.com/inward/record.url?scp=0028820432&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028820432&partnerID=8YFLogxK

M3 - Short survey

AN - SCOPUS:0028820432

VL - 7

SP - 44

EP - 49

JO - Journal of Myocardial Ischemia

JF - Journal of Myocardial Ischemia

SN - 1045-7984

IS - SUPPL. 1

ER -