Thymoma and cellular immune deficiency in an adolescent

Scott H. Sicherer, Michael D. Cabana, Elizabeth J. Perlman, Howard M. Lederman, Rebecca R. Matsakis, Jerry A. Winkelstein*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Thymoma has been associated with both humoral immunodeficiency and cellular immunodeficiency, but the latter association has never been described in the pediatric age group. We report a 15-year-old female with thymoma, recalcitrant oropharyngeal candidiasis, recurrent generalized cutaneous herpes simplex virus type 2 infection, recurrent pneumonia and myasthenia gravis. Pathology of the thymic lesion showed a 10 x 5 x 6 cm extensively hyalinized mass with residual regions of spindle cell predominant and lymphocyte-rich thymoma. There was no evidence of humoral immunodeficiency but there was clinical and laboratory evidence of cellular immunodeficiency with cutaneous anergy and absence of T cell proliferation to Candida antigen. Six weeks after the thymoma was resected, she was no longer anergic and Candida proliferation was normal, although she continued to experience infections. This is the first reported pediatric patient with an association of cellular immunodeficiency with thymoma.

Original languageEnglish (US)
Pages (from-to)49-52
Number of pages4
JournalPediatric Allergy and Immunology
Volume9
Issue number1
DOIs
StatePublished - Jan 1 1998

Keywords

  • Adolescent
  • Candidiasis
  • Immunodeficiency
  • Thymoma

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Immunology and Allergy
  • Immunology

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