Abstract
Thyroid hormone is essential for skeletal development and also affects mature bone. Depending on the hormone concentration and stage of life, the effects of thyroid hormone can be either beneficial or deleterious to the skeleton. This chapter focuses on the intracellular and cellular effects of thyroid hormone on bone cells as well as its relationship to the observed effects of the hormone on the skeleton in vivo in both experimental animals and humans. Studies published since the previous edition provide information on thyroid hormone effects on additional genes of interest in osteoblasts and further assessment of the skeletal risks of excess thyroid hormone.
Original language | English (US) |
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Title of host publication | Principles of Bone Biology |
Publisher | Elsevier |
Pages | 895-914 |
Number of pages | 20 |
ISBN (Electronic) | 9780128148419 |
DOIs | |
State | Published - Jan 1 2019 |
Keywords
- Bone
- Hormone
- Osteoblasts
- Osteoporosis
- Thyroid
- Thyroid hormon
ASJC Scopus subject areas
- General Agricultural and Biological Sciences
- General Biochemistry, Genetics and Molecular Biology
- General Medicine