Thyroid Medullary Carcinoma and Absent Histamine Flare

L. M. Jampol, V. L. Jacson

Research output: Contribution to journalLetterpeer-review

2 Scopus citations


To the Editor: A case report in the Journal (N Engl J Med 284:963–964, 1971) described a patient with multiple neurofibromas, metastatic medullary carcinoma of the thyroid gland, bilateral pheochromocytomas and the characteristic physical appearance of this syndrome. Dr. Baum, in addition, noted absence of a flare response to intradermal histamine, ectopic lacrimal puncta, an abnormal Schirmer tests. A letter in the Journal (N Engl J Med 284:983, 1971) by Gorlin confirmed the absence of the flare response in patients with thyroid medullary carcinoma, probably because of elevated histaminase levels. We have been following a 16-year-old boy with the syndrome ….

Original languageEnglish (US)
Number of pages1
JournalNew England Journal of Medicine
Issue number12
StatePublished - Mar 23 1972

ASJC Scopus subject areas

  • General Medicine


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