Tight junction regulation through vesicle trafficking: Bringing cells together

Sarah J. Fletcher; Joshua Z. Rappoport

doi:10.1042/BST20130162

Tight junction regulation through vesicle trafficking: Bringing cells together

Sarah J. Fletcher, Joshua Z. Rappoport^*

^*Corresponding author for this work

Cell & Developmental Biology

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Epithelial layers are integral for many physiological processes and are maintained by intercellular adhesive structures. During disease, these structures can disassemble, leading to breakdown of epithelia. TJs (tight junctions) are one type of intercellular adhesion. Loss of TJs has been linked to the pathogenesis of many diseases. The present review focuses on the role of vesicle trafficking in regulation of TJs, in particular trafficking of the TJ protein occludin. We examine how endocytosis and endosomal recycling modulate occludin localization under steady-state conditions and during stimulated TJ disassembly.

Original language	English (US)
Pages (from-to)	195-200
Number of pages	6
Journal	Biochemical Society Transactions
Volume	42
Issue number	1
DOIs	https://doi.org/10.1042/BST20130162
State	Published - Feb 1 2014

Keywords

Endocytosis
Occludin
Recycling
Tight junction
Vesicle trafficking

ASJC Scopus subject areas

Biochemistry

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10.1042/BST20130162

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AB - Epithelial layers are integral for many physiological processes and are maintained by intercellular adhesive structures. During disease, these structures can disassemble, leading to breakdown of epithelia. TJs (tight junctions) are one type of intercellular adhesion. Loss of TJs has been linked to the pathogenesis of many diseases. The present review focuses on the role of vesicle trafficking in regulation of TJs, in particular trafficking of the TJ protein occludin. We examine how endocytosis and endosomal recycling modulate occludin localization under steady-state conditions and during stimulated TJ disassembly.

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KW - Occludin

KW - Recycling

KW - Tight junction

KW - Vesicle trafficking

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Tight junction regulation through vesicle trafficking: Bringing cells together

Abstract

Keywords

ASJC Scopus subject areas

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