TY - JOUR
T1 - Time-dependent inhibition of neuronal nitric oxide synthase by N-propargylguanidine
AU - Fast, Walter
AU - Huff, Mary Elizabeth
AU - Silverman, Richard B.
N1 - Funding Information:
Acknowledgments The authors are grateful to the National Institutes of Health for financial (GM49725) and for support of W.F. through NIH Training Grant T32 GM08382.
PY - 1997/6/3
Y1 - 1997/6/3
N2 - N-Propargylguanidine was synthesized and found to be a time-dependent inhibitor of neuronal nitric oxide synthase from bovine brain. No inactivation occurs when NADP+ is substituted for NADPH, inhibition is blocked by L-arginine, but not D-arginine, and no enzyme reactivation occurs by dilution of inactivated enzyme with excess L-arginine.
AB - N-Propargylguanidine was synthesized and found to be a time-dependent inhibitor of neuronal nitric oxide synthase from bovine brain. No inactivation occurs when NADP+ is substituted for NADPH, inhibition is blocked by L-arginine, but not D-arginine, and no enzyme reactivation occurs by dilution of inactivated enzyme with excess L-arginine.
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U2 - 10.1016/S0960-894X(97)00241-2
DO - 10.1016/S0960-894X(97)00241-2
M3 - Article
AN - SCOPUS:0030958016
SN - 0960-894X
VL - 7
SP - 1449
EP - 1454
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
IS - 11
ER -