Time-dependent inhibition of neuronal nitric oxide synthase by N-propargylguanidine

Walter Fast, Mary Elizabeth Huff, Richard B. Silverman*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


N-Propargylguanidine was synthesized and found to be a time-dependent inhibitor of neuronal nitric oxide synthase from bovine brain. No inactivation occurs when NADP+ is substituted for NADPH, inhibition is blocked by L-arginine, but not D-arginine, and no enzyme reactivation occurs by dilution of inactivated enzyme with excess L-arginine.

Original languageEnglish (US)
Pages (from-to)1449-1454
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Issue number11
StatePublished - Jun 3 1997

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry


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