Time for a neonatal-specific consensus definition for sepsis

James L. Wynn*, Hector R. Wong, Thomas P. Shanley, Matthew J. Bizzarro, Lisa Saiman, Richard A. Polin

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

202 Scopus citations


OBJECTIVE: To review the accuracy of the pediatric consensus definition of sepsis in term neonates and to determine the definition of neonatal sepsis used. STUDY SELECTION: The review focused primarily on pediatric literature relevant to the topic of interest. CONCLUSIONS: Neonatal sepsis is variably defined based on a number of clinical and laboratory criteria that make the study of this common and devastating condition very difficult. Diagnostic challenges and uncertain disease epidemiology necessarily result from a variable definition of disease. In 2005, intensivists caring for children recognized that as new drugs became available, children would be increasingly studied and thus, pediatric-specific consensus definitions were needed. Pediatric sepsis criteria are not accurate for term neonates and have not been examined in preterm neonates for whom the developmental stage influences aberrations associated with host immune response. Thus, specific consensus definitions for both term and preterm neonates are needed. Such definitions are critical for the interpretation of observational studies, future training of scientists and practitioners, and implementation of clinical trials in neonates.

Original languageEnglish (US)
Pages (from-to)523-528
Number of pages6
JournalPediatric Critical Care Medicine
Issue number6
StatePublished - Jul 2014

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine
  • Pediatrics, Perinatology, and Child Health


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