TY - JOUR
T1 - Time frames for analysis of inflammatory mediators in acute pancreatitis
T2 - Improving admission triage
AU - Duarte-Rojo, Andrés
AU - Suazo-Barahona, Jorge
AU - Ramírez-Iglesias, María Teresa
AU - Uscanga, Luis F.
AU - Robles-Díaz, Guillermo
PY - 2009/10
Y1 - 2009/10
N2 - Improving the outcome of acute pancreatitis through prognostic markers has been a matter of ample research. We evaluate the clinical usefulness of four serum markers in comparison to Ranson's score. Serum measurements of C-reactive protein (CRP), interleukin-6, -10 (IL-6, IL-10), and pancreatitis-associated protein (PAP) were performed. The usefulness of each marker for predicting severity was compared with that of Ranson's score. Time of evolution was considered for improving their usefulness. Seventy-one patients were studied. Severe cases had higher levels of all markers, although only IL-10 had better accuracy than Ranson's. In patients admitted during the first 48 h, IL-6, IL-10, and PAP had improved accuracy over Ranson's; however, after this time frame, only CRP outperformed Ranson's score. Analysis of time frames improved the accuracy of all markers. Therefore, time of evolution should be considered when using these parameters for a better prognosis.
AB - Improving the outcome of acute pancreatitis through prognostic markers has been a matter of ample research. We evaluate the clinical usefulness of four serum markers in comparison to Ranson's score. Serum measurements of C-reactive protein (CRP), interleukin-6, -10 (IL-6, IL-10), and pancreatitis-associated protein (PAP) were performed. The usefulness of each marker for predicting severity was compared with that of Ranson's score. Time of evolution was considered for improving their usefulness. Seventy-one patients were studied. Severe cases had higher levels of all markers, although only IL-10 had better accuracy than Ranson's. In patients admitted during the first 48 h, IL-6, IL-10, and PAP had improved accuracy over Ranson's; however, after this time frame, only CRP outperformed Ranson's score. Analysis of time frames improved the accuracy of all markers. Therefore, time of evolution should be considered when using these parameters for a better prognosis.
KW - Acute pancreatitis
KW - Interleukins
KW - Pancreatitis-associated protein
KW - Prognosis
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U2 - 10.1007/s10620-008-0615-1
DO - 10.1007/s10620-008-0615-1
M3 - Article
C2 - 19082718
AN - SCOPUS:70149105239
SN - 0163-2116
VL - 54
SP - 2282
EP - 2287
JO - Digestive diseases and sciences
JF - Digestive diseases and sciences
IS - 10
ER -