Time-resolved magnetic resonance angiography: Evaluation of intrapulmonary circulation parameters in pulmonary arterial hypertension

Hyun J. Jeong, Parmede Vakil, John J. Sheehan, Sanjiv J. Shah, Michael Cuttica, James C. Carr, Timothy J. Carroll, Amir Davarpanah

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

Purpose To determine whether pulmonary arterial and venous transit times measured by time-resolved magnetic resonance angiography (MRA) can be used as a diagnostic tool for pulmonary arterial hypertension (PAH). Materials and Methods Twelve patients with confirmed PAH and 10 healthy volunteers were scanned with Institutional Review Board (IRB) approval. Time-resolved MRA and 2D phase contrast flow images of the pulmonary vasculature were acquired. Pulmonary arterial and venous transit times (PaTT and PvTT) and pulmonary valve flow (PVF) were obtained. Pulmonary arterial and pulmonary venous blood volumes (PaBV and PvBV) were calculated as the product of flow and transit time. Results Patients with PAH showed statistically significant increases in PaTT and PvTT (P < 0.0004, P < 0.05, respectively) compared to controls. PaBV (165.2 ± 92.0 mL) was significantly higher in PAH subjects than controls (97.0 ± 47.1 mL) (P < 0.04), whereas PvBV (127.9 ± 148.9 mL) of PAH subjects had no significant increase from those of healthy controls (142.5 ± 104.1 mL) (P < 0.38). Conclusion Pulmonary arterial transit times measured using time-resolved MRA can be used as a simple, noninvasive metric for detection of altered hemodynamics in PAH.

Original languageEnglish (US)
Pages (from-to)225-231
Number of pages7
JournalJournal of Magnetic Resonance Imaging
Volume33
Issue number1
DOIs
StatePublished - Jan 2011

Keywords

  • angiography
  • contrast-enhanced
  • pulmonary hypertension
  • time-resolved

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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