TY - JOUR
T1 - Timing of meals
T2 - When is as critical as what and how much
AU - Jiang, Peng
AU - Turek, Fred W.
N1 - Funding Information:
This work is supported by National Institute on Aging Grant NIH P01 AG011412.
PY - 2017/5
Y1 - 2017/5
N2 - Over the past decade, a large body of literature has demonstrated that disruptions of the endogenous circadian clock, whether environmental or genetic, lead to metabolic dysfunctions that are associated with obesity, diabetes, and other metabolic disorders. The phrase, “It is not only what you eat and how much you eat, but also when you eat” sends a simple message about circadian timing and body weight regulation. Communicating this message to clinicians and patients, while also elucidating the neuroendocrine, molecular, and genetic mechanisms underlying this phrase is essential to embrace the growing knowledge of the circadian impact on metabolism as a part of healthy life style as well as to incorporate it into clinical practice for improvement of overall human health. In this review, we discuss findings from animal models, as well as epidemiological and clinical studies in humans, which collectively promote the awareness of the role of circadian clock in metabolic functions and dysfunctions.
AB - Over the past decade, a large body of literature has demonstrated that disruptions of the endogenous circadian clock, whether environmental or genetic, lead to metabolic dysfunctions that are associated with obesity, diabetes, and other metabolic disorders. The phrase, “It is not only what you eat and how much you eat, but also when you eat” sends a simple message about circadian timing and body weight regulation. Communicating this message to clinicians and patients, while also elucidating the neuroendocrine, molecular, and genetic mechanisms underlying this phrase is essential to embrace the growing knowledge of the circadian impact on metabolism as a part of healthy life style as well as to incorporate it into clinical practice for improvement of overall human health. In this review, we discuss findings from animal models, as well as epidemiological and clinical studies in humans, which collectively promote the awareness of the role of circadian clock in metabolic functions and dysfunctions.
KW - Circadian clock
KW - Metabolism
KW - Obesity
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U2 - 10.1152/ajpendo.00295.2016
DO - 10.1152/ajpendo.00295.2016
M3 - Review article
C2 - 28143856
AN - SCOPUS:85018773589
VL - 312
SP - E369-E380
JO - American Journal of Physiology
JF - American Journal of Physiology
SN - 0193-1849
IS - 5
ER -