Tip-enhanced raman imaging: An emergent tool for probing biology at the nanoscale

Eric A. Pozzi, Matthew D. Sonntag, Nan Jiang, Jordan M. Klingsporn, Mark C. Hersam, Richard P. Van Duyne*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

76 Scopus citations


Typically limited by the diffraction of light, most optical spectroscopy methods cannot provide the spatial resolution necessary to characterize specimens at the nanoscale. An emerging exception to this rule is tip-enhanced Raman spectroscopy (TERS), which overcomes the diffraction limit through electromagnetic field localization at the end of a sharp metallic tip. As demonstrated by the Zenobi group in this issue of ACS Nano, TER imaging is an analytical technique capable of providing high-resolution chemical maps of biological samples. In this Perspective, we highlight recent advances and future applications of TER imaging as a technique for interrogating biology at the nanoscale.

Original languageEnglish (US)
Pages (from-to)885-888
Number of pages4
JournalACS nano
Issue number2
StatePublished - Feb 26 2013

ASJC Scopus subject areas

  • Materials Science(all)
  • Engineering(all)
  • Physics and Astronomy(all)


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