Tissue engineering for the oncologic urinary bladder

Tomasz Drewa*, Jan Adamowicz, Arun Sharma

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

32 Scopus citations

Abstract

Urinary diversion after radical cystectomy in patients with bladder cancer normally takes the form of an ileal conduit or neobladder. However, such diversions are associated with a number of complications including increased risk of infection. A plausible alternative is the construction of a neobladder (or bladder tissue) in vitro using autologous cells harvested from the patient. Biomaterials can be used as a scaffold for naturally occurring regenerative stem cells to latch onto to regrow the bladder smooth muscle and epithelium. Such engineered tissues show great promise in urologic tissue regeneration, but are faced with a number of challenges. For example, the differentiation mesenchymal stem cells from various sources can be difficult and the smooth muscle cells formed do not precisely mimic the natural cells.

Original languageEnglish (US)
Pages (from-to)561-572
Number of pages12
JournalNature Reviews Urology
Volume9
Issue number10
DOIs
StatePublished - Oct 1 2012

ASJC Scopus subject areas

  • Urology

Fingerprint Dive into the research topics of 'Tissue engineering for the oncologic urinary bladder'. Together they form a unique fingerprint.

Cite this