Tissue-microarrays. Ein hochdurchsatzverfahren zur verifizierung potenzieller biomarker

Translated title of the contribution: Tissue microarrays. High-throughput procedures to verify potential biomarkers

R. Kuefer*, M. D. Hofer, J. E. Gschwend, M. A. Rubin

*Corresponding author for this work

Research output: Contribution to journalReview article

14 Scopus citations

Abstract

High-throughput molecular screening tools have created a need for equally rapid means to verify potential biomarkers. Tissue microarray (TMA) technology facilitates effective analysis on the protein level. Hundreds of 0.6-mm-diameter tissue samples are placed on a single standard glass slide. This approach allows analysis with different in situ methods of all tissue samples in one experiment under standardized conditions. TMAs are not only perfectly suited for molecular epidemiologic studies if applied on multitumor arrays composed of a variety of tumor entities, but they are also used for tumor-specific investigations of molecular markers. In this report the technical aspects of TMAs as a miniaturized high-throughput technology are described. We further demonstrate how the TMA technique will help to accelerate the transition from basic research to clinical application in prostate cancer disease.

Translated title of the contributionTissue microarrays. High-throughput procedures to verify potential biomarkers
Original languageGerman
Pages (from-to)659-667
Number of pages9
JournalUrologe - Ausgabe A
Volume43
Issue number6
StatePublished - Jun 1 2004

Keywords

  • Biomarkers
  • Prostate cancer
  • TMA
  • Tissue microarray

ASJC Scopus subject areas

  • Urology

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