Tissue plasminogen activator and inhibitors of fibrinolysis in malignant melanoma(with 1 color plate)

Hau C. Kwaan*, James A. Radosevich, Cong Gao Xu, Clara Lastre

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Various human malignant tumors including malignant melanoma showed an absence of fibrinolytic activity in previous histochemical fibrin studies. In contrast, a tissue plasminogen activator has been isolated both from extracts of melanoma tissues and melanoma cell lines in culture and has been characterized to be a potent plasminogen activator. In an attempt to resolve this apparent discrepancy, we studied biopsies specimens of melanoma, several melanoma cell lines and melanoma xenografts by the immunoperoxidase method. Tissue plasminogen activator was observed in melanoma tissues, cell lines and xenografts, while various inhibitors of fibrinolysis, including α2-antiplasmin, α2-macroglobulin, α1-antitrypsin and antithrombin III, were found intracellularly only in the melanoma tumor cells but not in melanoma cell lines nor in xenografts. We believe that these inhibitors are derived from the blood and are bound to the tissue plasminogen activator within the melanoma cells. Their presence in tumor cells would explain the lack of fibrinolytic activity in melanoma tissues.

Original languageEnglish (US)
Pages (from-to)301-306
Number of pages6
JournalTumor Biology
Volume9
Issue number6
DOIs
StatePublished - Jan 1 1988

Keywords

  • Fibrinolysis
  • Inhibitors
  • Malignant melanoma
  • Tissue plasminogen activator

ASJC Scopus subject areas

  • Cancer Research

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