Tissue-specific estrogen biosynthesis and metabolism

Evan R. Simpson; Colin Clyne; Caroline Speed; Gary Rubin; Serdar Bulun

doi:10.1111/j.1749-6632.2001.tb04002.x

Tissue-specific estrogen biosynthesis and metabolism

Evan R. Simpson^*, Colin Clyne, Caroline Speed, Gary Rubin, Serdar Bulun

^*Corresponding author for this work

Obstetrics and Gynecology

Research output: Contribution to journal › Article › peer-review

66 Scopus citations

Abstract

While the ovaries are the principal source of systemic estrogen in the premenopausal nonpregnant woman, other sites of estrogen biosynthesis are present throughout the body and these become the major sources of estrogen beyond menopause. These extragonadal sources of estrogen are small, but may play an important, though hitherto largely unrecognized, physiological and pathophysiological role. Aromatase activity in extragonadal sites contributes to this source of estrogen and may contribute to breast tumor development and/or growth. Selective aromatase modulators (SAMs) may have a role to play in the treatment of estrogen-dependent diseases, such as breast cancer.

Original language	English (US)
Pages (from-to)	58-67
Number of pages	10
Journal	Annals of the New York Academy of Sciences
Volume	949
DOIs	https://doi.org/10.1111/j.1749-6632.2001.tb04002.x
State	Published - 2001

Keywords

Aromatase
ERα
ERβ
SAMs

ASJC Scopus subject areas

General Neuroscience
General Biochemistry, Genetics and Molecular Biology
History and Philosophy of Science

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1111/j.1749-6632.2001.tb04002.x

Cite this

@article{00ef02be28a548c39e7e3b8448eb05af,

title = "Tissue-specific estrogen biosynthesis and metabolism",

abstract = "While the ovaries are the principal source of systemic estrogen in the premenopausal nonpregnant woman, other sites of estrogen biosynthesis are present throughout the body and these become the major sources of estrogen beyond menopause. These extragonadal sources of estrogen are small, but may play an important, though hitherto largely unrecognized, physiological and pathophysiological role. Aromatase activity in extragonadal sites contributes to this source of estrogen and may contribute to breast tumor development and/or growth. Selective aromatase modulators (SAMs) may have a role to play in the treatment of estrogen-dependent diseases, such as breast cancer.",

keywords = "Aromatase, ERα, ERβ, SAMs",

author = "Simpson, {Evan R.} and Colin Clyne and Caroline Speed and Gary Rubin and Serdar Bulun",

year = "2001",

doi = "10.1111/j.1749-6632.2001.tb04002.x",

language = "English (US)",

volume = "949",

pages = "58--67",

journal = "Annals of the New York Academy of Sciences",

issn = "0077-8923",

publisher = "John Wiley and Sons Inc.",

}

TY - JOUR

T1 - Tissue-specific estrogen biosynthesis and metabolism

AU - Simpson, Evan R.

AU - Clyne, Colin

AU - Speed, Caroline

AU - Rubin, Gary

AU - Bulun, Serdar

PY - 2001

Y1 - 2001

N2 - While the ovaries are the principal source of systemic estrogen in the premenopausal nonpregnant woman, other sites of estrogen biosynthesis are present throughout the body and these become the major sources of estrogen beyond menopause. These extragonadal sources of estrogen are small, but may play an important, though hitherto largely unrecognized, physiological and pathophysiological role. Aromatase activity in extragonadal sites contributes to this source of estrogen and may contribute to breast tumor development and/or growth. Selective aromatase modulators (SAMs) may have a role to play in the treatment of estrogen-dependent diseases, such as breast cancer.

AB - While the ovaries are the principal source of systemic estrogen in the premenopausal nonpregnant woman, other sites of estrogen biosynthesis are present throughout the body and these become the major sources of estrogen beyond menopause. These extragonadal sources of estrogen are small, but may play an important, though hitherto largely unrecognized, physiological and pathophysiological role. Aromatase activity in extragonadal sites contributes to this source of estrogen and may contribute to breast tumor development and/or growth. Selective aromatase modulators (SAMs) may have a role to play in the treatment of estrogen-dependent diseases, such as breast cancer.

KW - Aromatase

KW - ERα

KW - ERβ

KW - SAMs

UR - http://www.scopus.com/inward/record.url?scp=0035687008&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035687008&partnerID=8YFLogxK

U2 - 10.1111/j.1749-6632.2001.tb04002.x

DO - 10.1111/j.1749-6632.2001.tb04002.x

M3 - Article

C2 - 11795380

AN - SCOPUS:0035687008

SN - 0077-8923

VL - 949

SP - 58

EP - 67

JO - Annals of the New York Academy of Sciences

JF - Annals of the New York Academy of Sciences

ER -

Tissue-specific estrogen biosynthesis and metabolism

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this