TNF-dependent apoptosis of L929 cells

A. B. Moshnikova*, K. E. Krotova, V. V. Galat, V. N. Afanasjev, V. B. Sadovnikov, I. P. Beletsky

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


We investigated the mode of TNF-dependent death of L929 murine fibroblasts and the influence of overexpression of bcl-2 family genes on this process. Based on morphological and biochemical data it has been shown that L929 cells died after TNF treatment by apoptosis irrespective of TNF dose and protein synthesis inhibition. Analysis of bcl-2 family gene transfectants revealed a down-regulation of TNF-induced apoptosis by bcl-2 and bclX overexpression, and an up-regulation by box gene.

Original languageEnglish (US)
Pages (from-to)566-567
Number of pages2
Issue number6
StatePublished - 2000

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology


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