TNF Receptor 1 Promotes Early-Life Immunity and Protects against Colitis in Mice

Cambrian Y. Liu, Sharon S. Tam, Ying Huang, Philip E. Dubé, Rabea Alhosh, Nandini Girish, Shivesh Punit, Shirin Nataneli, Fan Li, Jeffrey M. Bender, M. Kay Washington, D. Brent Polk*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Neutralization of tumor necrosis factor (TNF) represents a widely used therapeutic strategy for autoimmune diseases including inflammatory bowel disease (IBD). However, the fact that many patients with IBD are non-responsive to anti-TNF therapies suggests the need for a better understanding of TNF signaling in IBD. Here, we show that co-deletion of TNF receptor 1 (TNFR1, Tnfrsf1a) in the Il10−/− spontaneous colitis model exacerbates disease, resulting in very-early-onset inflammation after weaning. The disease can be interrupted by treatment with antibiotics. The single deletion of TNFR1 induces subclinical colonic epithelial dysfunction and mucosal immune abnormalities, including accumulation of neutrophils and depletion of B cells. During the pre-disease period (before weaning), both Tnfr1−/− and Il10−/− Tnfr1−/− animals exhibit impaired expression of pro-inflammatory cytokines compared with wild-type and Il10−/− controls, respectively. Collectively, these results demonstrate the net anti-inflammatory functions of TNF/TNFR1 signaling through the regulation of colonic immune homeostasis in early life.

Original languageEnglish (US)
Article number108275
JournalCell reports
Volume33
Issue number3
DOIs
StatePublished - Oct 20 2020

Keywords

  • IBD
  • antibiotics
  • barrier
  • microbiome
  • mucosa
  • tolerance
  • weaning reaction

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology

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