To cyclize or not to cyclize: Catching enzyme evolution in the act

Bradley S. Evans, Neil L. Kelleher

Research output: Contribution to journalShort survey

1 Scopus citations

Abstract

If you look at the biggest genes in soil and marine bacteria, you tend to see the chemical blueprints for making natural products such as peptides and polyketides. Over the past decade, collective efforts of enzymologists working with synthetic and analytical chemists have been catching up with the data dump from microbial genome sequencing. Following this story line, we now understand how cyanobacteria construct scaffolds for the related natural products curacin and jamaicamide using subtle tweaks to non-standard biosynthetic machinery.

Original languageEnglish (US)
Pages (from-to)495-497
Number of pages3
JournalACS chemical biology
Volume4
Issue number7
DOIs
StatePublished - Jul 17 2009

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine

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