To live or die: A critical decision for the lung

G. R.Scott Budinger, Jacob I. Sznajder*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

8 Scopus citations


Every cell in the body expresses a set of proteins designed to trigger permeabilization of the mitochondria and cell death. Inactivation or inappropriate triggering of these pathways is increasingly recognized as a contributor to human disease. A study in this issue of the JCI demonstrates that IL-6 exerts its protective effect against the development of lung injury following exposure of mice to 95% O2 by increasing the expression of a Bcl-2-related protein, A1 (see the related article beginning on page 1039). This protein acts to prevent mitochondrial membrane permeabilizarion and cell death following exposure to hyperoxia. The data in this study lend support to the hypothesis that inappropriate triggering of cell-death pathways may contribute to the development of hyperoxic pulmonary edema, lung injury, and respiratory failure.

Original languageEnglish (US)
Pages (from-to)828-830
Number of pages3
JournalJournal of Clinical Investigation
Issue number4
StatePublished - Apr 2005

ASJC Scopus subject areas

  • Medicine(all)


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