Tofacitinib Does Not Impair Sperm Quality in Men With Ulcerative Colitis

Anne Grosen; Emanuelle Bellaguarda; Ingela Liljeqvist-Soltic; Anne Bine Skytte; Stephen B. Hanauer; Jens Kelsen

doi:10.1093/ibd/izae195

Tofacitinib Does Not Impair Sperm Quality in Men With Ulcerative Colitis

Anne Grosen^*, Emanuelle Bellaguarda, Ingela Liljeqvist-Soltic, Anne Bine Skytte, Stephen B. Hanauer, Jens Kelsen

^*Corresponding author for this work

Medicine, Gastroenterology Division

Research output: Contribution to journal › Article › peer-review

Abstract

We demonstrate that tofacitinib does not adversely affect semen quality or sex hormones in male patients. These first postmarketing data for tofacitinib and semen quality are reassuring. Our study raises no safety concerns, though larger studies are needed to confirm our findings.

Original language	English (US)
Pages (from-to)	882-884
Number of pages	3
Journal	Inflammatory bowel diseases
Volume	31
Issue number	3
DOIs	https://doi.org/10.1093/ibd/izae195
State	Published - Mar 1 2025

Funding

The authors would like to thank all the participants in the study. Dorte Jensen and Marianne B. Rohde are acknowledged for their laboratory assistance. This work was supported in part by Digestive Health Foundation and Colitis-Crohn Denmark. The external funders were not involved in any aspect of the study or the writing of the report.

Keywords

male fertility
sperm DNA integrity
sperm quality
tofacitinib
ulcerative colitis

ASJC Scopus subject areas

Immunology and Allergy
Gastroenterology

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10.1093/ibd/izae195

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AU - Hanauer, Stephen B.

AU - Kelsen, Jens

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Tofacitinib Does Not Impair Sperm Quality in Men With Ulcerative Colitis

Abstract

Funding

Keywords

ASJC Scopus subject areas

Access to Document

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