Tolerance rendered by neonatal treatment with anti-idiotypic antibodies: Induction and maintenance in athymic mice

Byung S Kim*, Walter J. Hopkins

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Congenitally athymic (nude) mice of BALB/c background and their littermates were rendered unresponsive to the phosphorylcholine (PC) determinant by neonatal injection of anti-idiotypic antibodies. The kinetics of recovery from unresponsiveness were found to be similar for both groups when measured over a 20-week period. Spleen cells from suppressed, athymic mice did not respond to PC and were able to inhibit the response of normal cells to PC when tested in vitro. These results indicated that a population of specific suppressor cells, which may be responsible for induction and/or maintenance of unresponsiveness, can be generated in the absence of a thymic environment.

Original languageEnglish (US)
Pages (from-to)460-465
Number of pages6
JournalCellular Immunology
Volume35
Issue number2
DOIs
StatePublished - Jan 1 1978

ASJC Scopus subject areas

  • Immunology

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