Tolerance rendered by neonatal treatment with anti-idiotypic antibodies: Induction and maintenance in athymic mice

Byung S. Kim; Walter J. Hopkins

doi:10.1016/0008-8749(78)90164-8

Tolerance rendered by neonatal treatment with anti-idiotypic antibodies: Induction and maintenance in athymic mice

Byung S. Kim^*, Walter J. Hopkins

^*Corresponding author for this work

Microbiology-Immunology

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Congenitally athymic (nude) mice of BALB/c background and their littermates were rendered unresponsive to the phosphorylcholine (PC) determinant by neonatal injection of anti-idiotypic antibodies. The kinetics of recovery from unresponsiveness were found to be similar for both groups when measured over a 20-week period. Spleen cells from suppressed, athymic mice did not respond to PC and were able to inhibit the response of normal cells to PC when tested in vitro. These results indicated that a population of specific suppressor cells, which may be responsible for induction and/or maintenance of unresponsiveness, can be generated in the absence of a thymic environment.

Original language	English (US)
Pages (from-to)	460-465
Number of pages	6
Journal	Cellular Immunology
Volume	35
Issue number	2
DOIs	https://doi.org/10.1016/0008-8749(78)90164-8
State	Published - Feb 1978

Funding

1 Supported by a grant from Leukemia Research Foundation, NCI-CB-43998, AI-10242, AI-9268, and Northwestern University Funds for Cancer. s To whom requests for reprints should be addressed; Department of Microbiology-Immunology, Northwestern University Medical School, Chicago, Illinois 60611.

ASJC Scopus subject areas

Immunology

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10.1016/0008-8749(78)90164-8

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title = "Tolerance rendered by neonatal treatment with anti-idiotypic antibodies: Induction and maintenance in athymic mice",

abstract = "Congenitally athymic (nude) mice of BALB/c background and their littermates were rendered unresponsive to the phosphorylcholine (PC) determinant by neonatal injection of anti-idiotypic antibodies. The kinetics of recovery from unresponsiveness were found to be similar for both groups when measured over a 20-week period. Spleen cells from suppressed, athymic mice did not respond to PC and were able to inhibit the response of normal cells to PC when tested in vitro. These results indicated that a population of specific suppressor cells, which may be responsible for induction and/or maintenance of unresponsiveness, can be generated in the absence of a thymic environment.",

author = "Kim, {Byung S.} and Hopkins, {Walter J.}",

note = "Funding Information: 1 Supported by a grant from Leukemia Research Foundation, NCI-CB-43998, AI-10242, AI-9268, and Northwestern University Funds for Cancer. s To whom requests for reprints should be addressed; Department of Microbiology-Immunology, Northwestern University Medical School, Chicago, Illinois 60611.",

year = "1978",

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doi = "10.1016/0008-8749(78)90164-8",

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T1 - Tolerance rendered by neonatal treatment with anti-idiotypic antibodies

T2 - Induction and maintenance in athymic mice

AU - Kim, Byung S.

AU - Hopkins, Walter J.

N1 - Funding Information: 1 Supported by a grant from Leukemia Research Foundation, NCI-CB-43998, AI-10242, AI-9268, and Northwestern University Funds for Cancer. s To whom requests for reprints should be addressed; Department of Microbiology-Immunology, Northwestern University Medical School, Chicago, Illinois 60611.

PY - 1978/2

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N2 - Congenitally athymic (nude) mice of BALB/c background and their littermates were rendered unresponsive to the phosphorylcholine (PC) determinant by neonatal injection of anti-idiotypic antibodies. The kinetics of recovery from unresponsiveness were found to be similar for both groups when measured over a 20-week period. Spleen cells from suppressed, athymic mice did not respond to PC and were able to inhibit the response of normal cells to PC when tested in vitro. These results indicated that a population of specific suppressor cells, which may be responsible for induction and/or maintenance of unresponsiveness, can be generated in the absence of a thymic environment.

AB - Congenitally athymic (nude) mice of BALB/c background and their littermates were rendered unresponsive to the phosphorylcholine (PC) determinant by neonatal injection of anti-idiotypic antibodies. The kinetics of recovery from unresponsiveness were found to be similar for both groups when measured over a 20-week period. Spleen cells from suppressed, athymic mice did not respond to PC and were able to inhibit the response of normal cells to PC when tested in vitro. These results indicated that a population of specific suppressor cells, which may be responsible for induction and/or maintenance of unresponsiveness, can be generated in the absence of a thymic environment.

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Tolerance rendered by neonatal treatment with anti-idiotypic antibodies: Induction and maintenance in athymic mice

Abstract

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