Toluene diisocyanate respiratory reactions: I. Reassessment of the problem’

Roy Patterson*, Frederick E. Hargreave, Leslie C. Grammer, Kathleen E. Harris, Jerry Dolovich, Roy Patterson*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


A series of workers with exposure to and respiratory symptoms from toluene diisocyanate (TDI) was compared with a group of exposed, asymptomatic workers and with normal controls using immunologic and clinical evaluations. Improved understanding of TDI-induced respiratory disease may best be achieved by categorizing the symptomatic workers into at least 3 and possibly 4 groups: Immunologic TDI asthma; pre-existing chronic respiratory disease exacerbated or unaffected by TDI; asthma coincidental with TDI exposure, and possibly TDI respiratory disease secondary to toxic or inflammatory mechanisms.

Original languageEnglish (US)
Pages (from-to)93-100
Number of pages8
JournalInternational archives of allergy and immunology
Issue number1
StatePublished - 1987

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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