Toluene diisocyanate respiratory reactions: I. Reassessment of the problem’

Roy Patterson; Frederick E. Hargreave; Leslie C. Grammer; Kathleen E. Harris; Jerry Dolovich; Roy Patterson

doi:10.1159/000234404

Toluene diisocyanate respiratory reactions: I. Reassessment of the problem’

Roy Patterson^*, Frederick E. Hargreave, Leslie C. Grammer, Kathleen E. Harris, Jerry Dolovich, Roy Patterson^*

^*Corresponding author for this work

Medicine

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

A series of workers with exposure to and respiratory symptoms from toluene diisocyanate (TDI) was compared with a group of exposed, asymptomatic workers and with normal controls using immunologic and clinical evaluations. Improved understanding of TDI-induced respiratory disease may best be achieved by categorizing the symptomatic workers into at least 3 and possibly 4 groups: Immunologic TDI asthma; pre-existing chronic respiratory disease exacerbated or unaffected by TDI; asthma coincidental with TDI exposure, and possibly TDI respiratory disease secondary to toxic or inflammatory mechanisms.

Original language	English (US)
Pages (from-to)	93-100
Number of pages	8
Journal	International archives of allergy and immunology
Volume	84
Issue number	1
DOIs	https://doi.org/10.1159/000234404
State	Published - 1987

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1159/000234404

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abstract = "A series of workers with exposure to and respiratory symptoms from toluene diisocyanate (TDI) was compared with a group of exposed, asymptomatic workers and with normal controls using immunologic and clinical evaluations. Improved understanding of TDI-induced respiratory disease may best be achieved by categorizing the symptomatic workers into at least 3 and possibly 4 groups: Immunologic TDI asthma; pre-existing chronic respiratory disease exacerbated or unaffected by TDI; asthma coincidental with TDI exposure, and possibly TDI respiratory disease secondary to toxic or inflammatory mechanisms.",

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AU - Harris, Kathleen E.

AU - Dolovich, Jerry

AU - Patterson, Roy

PY - 1987

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AB - A series of workers with exposure to and respiratory symptoms from toluene diisocyanate (TDI) was compared with a group of exposed, asymptomatic workers and with normal controls using immunologic and clinical evaluations. Improved understanding of TDI-induced respiratory disease may best be achieved by categorizing the symptomatic workers into at least 3 and possibly 4 groups: Immunologic TDI asthma; pre-existing chronic respiratory disease exacerbated or unaffected by TDI; asthma coincidental with TDI exposure, and possibly TDI respiratory disease secondary to toxic or inflammatory mechanisms.

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Toluene diisocyanate respiratory reactions: I. Reassessment of the problem’

Abstract

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UN SDGs

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