Top-down proteomics

Neil L. Kelleher*

*Corresponding author for this work

Research output: Contribution to journalReview article

365 Scopus citations

Abstract

The most rigorous definition of a top-down experiment involves high-resolution measurement of an intact molecular weight value and direct fragmentation of protein ions in the gas phase. Neil L. Kelleher at the University of Illinois at Urbana-Champaign describes how this technique turns MS data from whole and fragmented proteins into biological information-and the challenges that still remain.

Original languageEnglish (US)
JournalAnalytical Chemistry
Volume76
Issue number11
StatePublished - Jul 12 2004

ASJC Scopus subject areas

  • Analytical Chemistry

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