Top-down proteomics

Neil L. Kelleher*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

455 Scopus citations


The most rigorous definition of a top-down experiment involves high-resolution measurement of an intact molecular weight value and direct fragmentation of protein ions in the gas phase. Neil L. Kelleher at the University of Illinois at Urbana-Champaign describes how this technique turns MS data from whole and fragmented proteins into biological information-and the challenges that still remain.

Original languageEnglish (US)
JournalAnalytical Chemistry
Issue number11
StatePublished - Jul 12 2004

ASJC Scopus subject areas

  • Analytical Chemistry


Dive into the research topics of 'Top-down proteomics'. Together they form a unique fingerprint.

Cite this