Topical calcineurin inhibitors for pediatric periorificial dermatitis

Ayelet Ollech*, Rame Yousif, Lacey Kruse, Annette Wagner, Brandi Kenner-Bell, Sarah Chamlin, Duri Yun, Lisa Shen, Karina Vivar, Megan Reynolds, Amy S. Paller, Anthony J. Mancini

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Data regarding the treatment of periorificial dermatitis with topical calcineurin inhibitors (TCI) in the pediatric population are limited. Objective: To assess the clinical utility of TCI in pediatric patients with periorificial dermatitis. Methods: A retrospective medical record review of all pediatric patients with periorificial dermatitis treated with TCIs was performed. Follow-up via telephone was performed to capture missing data. Results: A total of 132 patients met the inclusion criteria. The median age at diagnosis was 4.2 years (interquartile range, 2.3-8.2). The median follow-up was 5.2 months (interquartile range, 2.1-11.7). Seventy-two patients had evaluable follow-up data. Of these, 48 (67%) patients were treated with TCI alone, 12 (16.7%) were treated with a combination of TCI and topical metronidazole, and 9 (12.5%) were treated with a combination of TCI and a systemic antibiotic. Complete response was noted in 68.8% of patients treated with TCI alone, in 75% of patients treated with TCI and metronidazole, and in 77.8% of patients treated with TCI and a systemic antibiotic. Adverse events were rare and mild in severity. Conclusion: Topical calcineurin inhibitors are an effective therapeutic option for pediatric patients with periorificial dermatitis and were well tolerated in this cohort.

Original languageEnglish (US)
Pages (from-to)1409-1414
Number of pages6
JournalJournal of the American Academy of Dermatology
Volume82
Issue number6
DOIs
StatePublished - Jun 2020

Keywords

  • azithromycin
  • erythromycin
  • minocycline
  • pediatric dermatology
  • perioral dermatitis
  • periorificial dermatitis
  • pimecrolimus
  • tacrolimus
  • topical calcineurin inhibitor
  • topical metronidazole

ASJC Scopus subject areas

  • Dermatology

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