Topical cholesterol/lovastatin for the treatment of porokeratosis: A pathogenesis-directed therapy

Lihi Atzmony, Young H. Lim, Claire Hamilton, Jonathan S. Leventhal, Annette Wagner, Amy S. Paller, Keith A. Choate*

*Corresponding author for this work

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Background: Porokeratosis is associated with mevalonate pathway gene mutations. Therapeutic options are few and often limited in efficacy. We hypothesized that topical therapy that aims to replenish cholesterol, an essential mevalonate pathway end-product, and block the accumulation of mevalonate pathway toxic metabolites could alleviate porokeratosis. Objective: To study the efficacy of topical cholesterol/lovastatin in different variants of porokeratosis. Methods: We enrolled a series of 5 porokeratosis patients,1 with disseminated superficial actinic porokeratosis, 2 with porokeratosis palmaris et plantaris disseminata, and 2 with linear porokeratosis. Patients were genotyped before initiation of therapy. Patients then applied topical cholesterol/lovastatin twice daily to a unilaterally defined treatment area for up to 3 months. The response was evaluated and patients photographed at every visit. Results: Three patients had MVD mutations, and 2 patients had PMVK mutations. Treatment with topical cholesterol/lovastatin (but not cholesterol alone) resulted in near complete clearance of disseminated superficial actinic porokeratosis lesions after 4 weeks of therapy and moderate improvement of porokeratosis palmaris et plantaris disseminata lesions and linear porokeratosis lesions. There were no adverse events. Limitations: Case series design with a small number of patients. Conclusion: Topical cholesterol/lovastatin is an effective and well-tolerated therapy for porokeratosis that underscores the utility of a pathogenesis-based therapy that replaces deficient end products and prevents accumulation of potentially toxic precursors.

Original languageEnglish (US)
Pages (from-to)123-131
Number of pages9
JournalJournal of the American Academy of Dermatology
Volume82
Issue number1
DOIs
Publication statusPublished - Jan 2020

    Fingerprint

Keywords

  • cholesterol
  • disseminated superficial actinic porokeratosis
  • genetic skin diseases
  • genetics
  • linear porokeratosis
  • medical dermatology
  • mevalonate pathway
  • pediatric dermatology
  • porokeratosis
  • statins
  • therapy
  • topical therapy

ASJC Scopus subject areas

  • Dermatology

Cite this