Topically Applied Imiquimod Inhibits Vascular Tumor Growth In Vivo

Robert Sidbury, Nicole Neuschler, Erin Neuschler, Ping Sun, Xiao Qi Wang, Richard Miller, Mark Tomai, Elena Puscasiu, Sajiv Gugneja, Amy S. Paller*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

98 Scopus citations

Abstract

Vascular tumors occur in approximately 10% of all infants and may be associated with significant morbidity. Available therapies for vascular tumors, such as systemic corticosteroids, vincristine, and interferon-α, may cause toxicity, limiting their use to complicated cases. Using a mouse hemangioendothelioma model, we investigated the efficacy and mechanism of action of imiquimod, a topically applied inducer of cytokines. Application of imiquimod cream, whether initiated at the time of cell inoculation or when tumors became visible, significantly decreased tumor growth and increased animal survival in comparison with control mice. Imiquimod-treated tumors showed decreased tumor cell proliferation, increased tumor apoptosis, and increased expression of tissue inhibitor of matrix metalloproteinase-1 with decreased activity of matrix metalloproteinase-9. The demonstration that local application of imiquimod inhibits vascular tumor enlargement in the mouse vascular tumor model suggests a novel, less toxic means of treating infantile hemangioendotheliomas and perhaps other cutaneous vascular tumors.

Original languageEnglish (US)
Pages (from-to)1205-1209
Number of pages5
JournalJournal of Investigative Dermatology
Volume121
Issue number5
DOIs
StatePublished - Nov 2003

Keywords

  • Cytokines
  • Hemangioendothelioma
  • Neoplasm

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Dermatology
  • Cell Biology

Fingerprint

Dive into the research topics of 'Topically Applied Imiquimod Inhibits Vascular Tumor Growth In Vivo'. Together they form a unique fingerprint.

Cite this