Topiramate for phantom limb pain: A time-series analysis

R. Norman Harden*, Tim T. Houle, Thomas A. Remble, Wendy Lin, Kenten Wang, Samuel Saltz

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


There is growing evidence of topiramate's efficacy in treating neuropathic pain. This article reports a detailed analysis of the response of four amputee subjects with phantom limb pain. Individual time-series analyses revealed that three out of four amputee participants receiving topiramate had statistically significant decreases in pain, with the peak effect noted at 800 mg daily. This analysis supports a hypothesis that topiramate may be effective in reducing phantom limb pain, and suggests a definitive study is indicated.

Original languageEnglish (US)
Pages (from-to)375-378
Number of pages4
JournalPain Medicine
Issue number5
StatePublished - Sep 2005


  • Antiepileptics
  • Phantom Pain
  • Time-Series Analysis
  • Topiramate

ASJC Scopus subject areas

  • Clinical Neurology
  • Anesthesiology and Pain Medicine


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