Topiramate for phantom limb pain: A time-series analysis

R. Norman Harden; Tim T. Houle; Thomas A. Remble; Wendy Lin; Kenten Wang; Samuel Saltz

doi:10.1111/j.1526-4637.2005.00060.x

Topiramate for phantom limb pain: A time-series analysis

R. Norman Harden^*, Tim T. Houle, Thomas A. Remble, Wendy Lin, Kenten Wang, Samuel Saltz

^*Corresponding author for this work

Physical Medicine and Rehabilitation

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

There is growing evidence of topiramate's efficacy in treating neuropathic pain. This article reports a detailed analysis of the response of four amputee subjects with phantom limb pain. Individual time-series analyses revealed that three out of four amputee participants receiving topiramate had statistically significant decreases in pain, with the peak effect noted at 800 mg daily. This analysis supports a hypothesis that topiramate may be effective in reducing phantom limb pain, and suggests a definitive study is indicated.

Original language	English (US)
Pages (from-to)	375-378
Number of pages	4
Journal	Pain Medicine
Volume	6
Issue number	5
DOIs	https://doi.org/10.1111/j.1526-4637.2005.00060.x
State	Published - Sep 2005

Keywords

Antiepileptics
Phantom Pain
Time-Series Analysis
Topiramate

ASJC Scopus subject areas

Clinical Neurology
Anesthesiology and Pain Medicine

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10.1111/j.1526-4637.2005.00060.x

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AU - Wang, Kenten

AU - Saltz, Samuel

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AB - There is growing evidence of topiramate's efficacy in treating neuropathic pain. This article reports a detailed analysis of the response of four amputee subjects with phantom limb pain. Individual time-series analyses revealed that three out of four amputee participants receiving topiramate had statistically significant decreases in pain, with the peak effect noted at 800 mg daily. This analysis supports a hypothesis that topiramate may be effective in reducing phantom limb pain, and suggests a definitive study is indicated.

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KW - Topiramate

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Topiramate for phantom limb pain: A time-series analysis

Abstract

Keywords

ASJC Scopus subject areas

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