Topiramate for phantom limb pain: A time-series analysis

Robert N Harden*, Tim T. Houle, Thomas A. Remble, Wendy Lin, Kenten Wang, Samuel Saltz

*Corresponding author for this work

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

There is growing evidence of topiramate's efficacy in treating neuropathic pain. This article reports a detailed analysis of the response of four amputee subjects with phantom limb pain. Individual time-series analyses revealed that three out of four amputee participants receiving topiramate had statistically significant decreases in pain, with the peak effect noted at 800 mg daily. This analysis supports a hypothesis that topiramate may be effective in reducing phantom limb pain, and suggests a definitive study is indicated.

Original languageEnglish (US)
Pages (from-to)375-378
Number of pages4
JournalPain Medicine
Volume6
Issue number5
DOIs
StatePublished - Sep 1 2005

Keywords

  • Antiepileptics
  • Phantom Pain
  • Time-Series Analysis
  • Topiramate

ASJC Scopus subject areas

  • Clinical Neurology
  • Anesthesiology and Pain Medicine

Fingerprint Dive into the research topics of 'Topiramate for phantom limb pain: A time-series analysis'. Together they form a unique fingerprint.

  • Cite this

    Harden, R. N., Houle, T. T., Remble, T. A., Lin, W., Wang, K., & Saltz, S. (2005). Topiramate for phantom limb pain: A time-series analysis. Pain Medicine, 6(5), 375-378. https://doi.org/10.1111/j.1526-4637.2005.00060.x