Topographic organization of sensory projections to the olfactory bulb

Robert Vassar*, Steve K. Chao, Raquel Sitcheran, Jennifer M. Nuñez, Leslie B. Vosshall, Richard Axel

*Corresponding author for this work

Research output: Contribution to journalArticle

973 Scopus citations

Abstract

The detection of odorant receptor mRNAs within the axon terminals of sensory neurons has permitted us to ask whether neurons expressing a given receptor project their axons to common glomeruli within the olfactory bulb. In situ hybridization with five different receptor probes demonstrates that axons from neurons expressing a given receptor converge on one, or at most, a few glomeruli within the olfactory bulb. Moreover, the position of specific glomeruli is bilaterally symmetric and is constant in different individuals within a species. These data support a model in which exposure to a given odorant may result in the stimulation of a spatially restricted set of glomeruli, such that the individual odorants would be associated with specific topographic patterns of activity within the olfactory bulb.

Original languageEnglish (US)
Pages (from-to)981-991
Number of pages11
JournalCell
Volume79
Issue number6
DOIs
StatePublished - Dec 16 1994

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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    Vassar, R., Chao, S. K., Sitcheran, R., Nuñez, J. M., Vosshall, L. B., & Axel, R. (1994). Topographic organization of sensory projections to the olfactory bulb. Cell, 79(6), 981-991. https://doi.org/10.1016/0092-8674(94)90029-9