Topographical Distribution of Epileptogenic Tubers in Patients with Tuberous Sclerosis Complex

Benjamin M. Ellingson; Yoko Hirata; Akira Yogi; Elena Karavaeva; Kevin Leu; Davis C. Woodworth; Robert J. Harris; Dieter R. Enzmann; Joyce Y. Wu; Gary W. Mathern; Noriko Salamon

doi:10.1177/0883073815609151

Topographical Distribution of Epileptogenic Tubers in Patients with Tuberous Sclerosis Complex

Benjamin M. Ellingson^*, Yoko Hirata, Akira Yogi, Elena Karavaeva, Kevin Leu, Davis C. Woodworth, Robert J. Harris, Dieter R. Enzmann, Joyce Y. Wu, Gary W. Mathern, Noriko Salamon

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Tuberous sclerosis complex is a multisystem genetic syndrome often affecting the central nervous system. The purpose of the current study was to identify topographical patterns in the distribution specific to epileptogenic (n = 37) and nonepileptogenic (n = 544) tubers throughout the brain for a cohort of 23 tuberous sclerosis complex patients with a history of seizures. Tubers localized to the inferior parietal lobes, middle frontal lobes, middle temporal lobes, or central sulcus regions were associated with a high frequency of epileptogenic tubers. Epileptogenic tubers occurred statistically more frequently within the inferior parietal lobe and within the central sulcus region in children younger than 1 or between 1 and 3 years old, respectively. Results imply seizure activity in tuberous sclerosis complex patients can be associated with the location of cortical tubers.

Original language	English (US)
Pages (from-to)	636-645
Number of pages	10
Journal	Journal of child neurology
Volume	31
Issue number	5
DOIs	https://doi.org/10.1177/0883073815609151
State	Published - Apr 1 2016
Externally published	Yes

Keywords

analysis of differential involvement
epilepsy
population maps
seizures
topographic mapping
tuberous sclerosis complex
tuberous sclerosis complex

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Clinical Neurology

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10.1177/0883073815609151

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title = "Topographical Distribution of Epileptogenic Tubers in Patients with Tuberous Sclerosis Complex",

abstract = "Tuberous sclerosis complex is a multisystem genetic syndrome often affecting the central nervous system. The purpose of the current study was to identify topographical patterns in the distribution specific to epileptogenic (n = 37) and nonepileptogenic (n = 544) tubers throughout the brain for a cohort of 23 tuberous sclerosis complex patients with a history of seizures. Tubers localized to the inferior parietal lobes, middle frontal lobes, middle temporal lobes, or central sulcus regions were associated with a high frequency of epileptogenic tubers. Epileptogenic tubers occurred statistically more frequently within the inferior parietal lobe and within the central sulcus region in children younger than 1 or between 1 and 3 years old, respectively. Results imply seizure activity in tuberous sclerosis complex patients can be associated with the location of cortical tubers.",

keywords = "analysis of differential involvement, epilepsy, population maps, seizures, topographic mapping, tuberous sclerosis complex, tuberous sclerosis complex",

author = "Ellingson, {Benjamin M.} and Yoko Hirata and Akira Yogi and Elena Karavaeva and Kevin Leu and Woodworth, {Davis C.} and Harris, {Robert J.} and Enzmann, {Dieter R.} and Wu, {Joyce Y.} and Mathern, {Gary W.} and Noriko Salamon",

note = "Funding Information: The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: UCLA Institute for Molecular Medicine Seed Grant (BME); UCLA Radiology Exploratory Research Grant (BME); Foreign Fulbright Student Program, Department of the State, Institute for International Education (EK); National Institute of Health National Institute of General Medical Sciences training grant GM08042 (KL); and the University of California, Los Angeles Medical Scientist Training Program (KL). Publisher Copyright: {\textcopyright} The Author(s) 2015.",

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doi = "10.1177/0883073815609151",

language = "English (US)",

volume = "31",

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AU - Leu, Kevin

AU - Woodworth, Davis C.

AU - Harris, Robert J.

AU - Enzmann, Dieter R.

AU - Wu, Joyce Y.

AU - Mathern, Gary W.

AU - Salamon, Noriko

N1 - Funding Information: The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: UCLA Institute for Molecular Medicine Seed Grant (BME); UCLA Radiology Exploratory Research Grant (BME); Foreign Fulbright Student Program, Department of the State, Institute for International Education (EK); National Institute of Health National Institute of General Medical Sciences training grant GM08042 (KL); and the University of California, Los Angeles Medical Scientist Training Program (KL). Publisher Copyright: © The Author(s) 2015.

PY - 2016/4/1

Y1 - 2016/4/1

N2 - Tuberous sclerosis complex is a multisystem genetic syndrome often affecting the central nervous system. The purpose of the current study was to identify topographical patterns in the distribution specific to epileptogenic (n = 37) and nonepileptogenic (n = 544) tubers throughout the brain for a cohort of 23 tuberous sclerosis complex patients with a history of seizures. Tubers localized to the inferior parietal lobes, middle frontal lobes, middle temporal lobes, or central sulcus regions were associated with a high frequency of epileptogenic tubers. Epileptogenic tubers occurred statistically more frequently within the inferior parietal lobe and within the central sulcus region in children younger than 1 or between 1 and 3 years old, respectively. Results imply seizure activity in tuberous sclerosis complex patients can be associated with the location of cortical tubers.

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Topographical Distribution of Epileptogenic Tubers in Patients with Tuberous Sclerosis Complex

Abstract

Keywords

ASJC Scopus subject areas

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