Topographical Distribution of Epileptogenic Tubers in Patients with Tuberous Sclerosis Complex

Benjamin M. Ellingson*, Yoko Hirata, Akira Yogi, Elena Karavaeva, Kevin Leu, Davis C. Woodworth, Robert J. Harris, Dieter R. Enzmann, Joyce Y. Wu, Gary W. Mathern, Noriko Salamon

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Tuberous sclerosis complex is a multisystem genetic syndrome often affecting the central nervous system. The purpose of the current study was to identify topographical patterns in the distribution specific to epileptogenic (n = 37) and nonepileptogenic (n = 544) tubers throughout the brain for a cohort of 23 tuberous sclerosis complex patients with a history of seizures. Tubers localized to the inferior parietal lobes, middle frontal lobes, middle temporal lobes, or central sulcus regions were associated with a high frequency of epileptogenic tubers. Epileptogenic tubers occurred statistically more frequently within the inferior parietal lobe and within the central sulcus region in children younger than 1 or between 1 and 3 years old, respectively. Results imply seizure activity in tuberous sclerosis complex patients can be associated with the location of cortical tubers.

Original languageEnglish (US)
Pages (from-to)636-645
Number of pages10
JournalJournal of child neurology
Issue number5
StatePublished - Apr 1 2016
Externally publishedYes


  • analysis of differential involvement
  • epilepsy
  • population maps
  • seizures
  • topographic mapping
  • tuberous sclerosis complex
  • tuberous sclerosis complex

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology


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