Abstract
Tuberous sclerosis complex is a multisystem genetic syndrome often affecting the central nervous system. The purpose of the current study was to identify topographical patterns in the distribution specific to epileptogenic (n = 37) and nonepileptogenic (n = 544) tubers throughout the brain for a cohort of 23 tuberous sclerosis complex patients with a history of seizures. Tubers localized to the inferior parietal lobes, middle frontal lobes, middle temporal lobes, or central sulcus regions were associated with a high frequency of epileptogenic tubers. Epileptogenic tubers occurred statistically more frequently within the inferior parietal lobe and within the central sulcus region in children younger than 1 or between 1 and 3 years old, respectively. Results imply seizure activity in tuberous sclerosis complex patients can be associated with the location of cortical tubers.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 636-645 |
| Number of pages | 10 |
| Journal | Journal of child neurology |
| Volume | 31 |
| Issue number | 5 |
| DOIs | |
| State | Published - Apr 1 2016 |
Funding
The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: UCLA Institute for Molecular Medicine Seed Grant (BME); UCLA Radiology Exploratory Research Grant (BME); Foreign Fulbright Student Program, Department of the State, Institute for International Education (EK); National Institute of Health National Institute of General Medical Sciences training grant GM08042 (KL); and the University of California, Los Angeles Medical Scientist Training Program (KL).
Keywords
- analysis of differential involvement
- epilepsy
- population maps
- seizures
- topographic mapping
- tuberous sclerosis complex
- tuberous sclerosis complex
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Clinical Neurology