Topographical Distribution of Epileptogenic Tubers in Patients with Tuberous Sclerosis Complex

Benjamin M. Ellingson; Yoko Hirata; Akira Yogi; Elena Karavaeva; Kevin Leu; Davis C. Woodworth; Robert J. Harris; Dieter R. Enzmann; Joyce Y. Wu; Gary W. Mathern; Noriko Salamon

doi:10.1177/0883073815609151

Topographical Distribution of Epileptogenic Tubers in Patients with Tuberous Sclerosis Complex

Benjamin M. Ellingson^*, Yoko Hirata, Akira Yogi, Elena Karavaeva, Kevin Leu, Davis C. Woodworth, Robert J. Harris, Dieter R. Enzmann, Joyce Y. Wu, Gary W. Mathern, Noriko Salamon

^*Corresponding author for this work

Pediatrics

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Tuberous sclerosis complex is a multisystem genetic syndrome often affecting the central nervous system. The purpose of the current study was to identify topographical patterns in the distribution specific to epileptogenic (n = 37) and nonepileptogenic (n = 544) tubers throughout the brain for a cohort of 23 tuberous sclerosis complex patients with a history of seizures. Tubers localized to the inferior parietal lobes, middle frontal lobes, middle temporal lobes, or central sulcus regions were associated with a high frequency of epileptogenic tubers. Epileptogenic tubers occurred statistically more frequently within the inferior parietal lobe and within the central sulcus region in children younger than 1 or between 1 and 3 years old, respectively. Results imply seizure activity in tuberous sclerosis complex patients can be associated with the location of cortical tubers.

Original language	English (US)
Pages (from-to)	636-645
Number of pages	10
Journal	Journal of child neurology
Volume	31
Issue number	5
DOIs	https://doi.org/10.1177/0883073815609151
State	Published - Apr 1 2016

Keywords

analysis of differential involvement
epilepsy
population maps
seizures
topographic mapping
tuberous sclerosis complex
tuberous sclerosis complex

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Clinical Neurology

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title = "Topographical Distribution of Epileptogenic Tubers in Patients with Tuberous Sclerosis Complex",

abstract = "Tuberous sclerosis complex is a multisystem genetic syndrome often affecting the central nervous system. The purpose of the current study was to identify topographical patterns in the distribution specific to epileptogenic (n = 37) and nonepileptogenic (n = 544) tubers throughout the brain for a cohort of 23 tuberous sclerosis complex patients with a history of seizures. Tubers localized to the inferior parietal lobes, middle frontal lobes, middle temporal lobes, or central sulcus regions were associated with a high frequency of epileptogenic tubers. Epileptogenic tubers occurred statistically more frequently within the inferior parietal lobe and within the central sulcus region in children younger than 1 or between 1 and 3 years old, respectively. Results imply seizure activity in tuberous sclerosis complex patients can be associated with the location of cortical tubers.",

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author = "Ellingson, {Benjamin M.} and Yoko Hirata and Akira Yogi and Elena Karavaeva and Kevin Leu and Woodworth, {Davis C.} and Harris, {Robert J.} and Enzmann, {Dieter R.} and Wu, {Joyce Y.} and Mathern, {Gary W.} and Noriko Salamon",

note = "Funding Information: The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: UCLA Institute for Molecular Medicine Seed Grant (BME); UCLA Radiology Exploratory Research Grant (BME); Foreign Fulbright Student Program, Department of the State, Institute for International Education (EK); National Institute of Health National Institute of General Medical Sciences training grant GM08042 (KL); and the University of California, Los Angeles Medical Scientist Training Program (KL). Publisher Copyright: {\textcopyright} The Author(s) 2015.",

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AU - Harris, Robert J.

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AU - Wu, Joyce Y.

AU - Mathern, Gary W.

AU - Salamon, Noriko

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Topographical Distribution of Epileptogenic Tubers in Patients with Tuberous Sclerosis Complex

Abstract

Keywords

ASJC Scopus subject areas

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