Total arterial compliance is a major determinant of peak oxygen uptake

T. L M De Backer, S. G. Carlier, P. Segers, G. Armstrong, B. Haluska, N. Greenberg, T. H. Marwick, J. D. Thomas

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Total arterial compliance (TAC, defined as dV/dP) is a major component of the arterial system. A decreased TAC increases left ventricular load and has a detrimental effect on coronary perfusion. We sought to assess the influence of TAC on the functional reserve (VO2max). Fourteen patients (mean age 64±14y) with known or suspected coronary artery disease and eleven controls (34±5y) underwent supine bicycle exercise echocardiography. Audio Doppler signal output of the echocardiographic machine was digitized with a customized hardware and software interface simultaneously with carotid tonometry and ECG. TAC at rest was calculated by the pulse pressure method (PPM). By step-wise forward multivariate analysis, independent predictors of VO2max were patient versus control status, peak exercise cardiac output and TAC. The described PC-based acquisition system for tonometry and Doppler signals permits the assessment of ventricular function and arterial biomechanics.

Original languageEnglish (US)
Pages (from-to)181-184
Number of pages4
JournalComputers in Cardiology
DOIs
StatePublished - Jan 1 2001

ASJC Scopus subject areas

  • Computer Science Applications
  • Cardiology and Cardiovascular Medicine

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