Patrón de la distribución de colesterol total y cHDLen niños y adolescentes españoles: Estudio RICARDIN

Translated title of the contribution: Total cholesterol and HDL cholesterol distribution in Spanish children and adolescents: RICARDIN study

Carlos Brotons Cuixart*, Rafael Gabriel Sánchez, Javier Muñiz Garcia, Aïda Ribera Solé, Serafín Málaga Guerrero, Pedro E. Sáenz Aranzubia, M. Teresa Díaz González-Blanco, Marciano Sánchez Bayle, Máximo Sandín Domínguez, Vicente Bosch Giménez, Esther Gorostiza Garai, Darwin R. Labarthe, Arturo Fernández-Cruz

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

BACKGROUND: The RICARDIN Study -multicenter study of cardiovascular risk factors in children and adolescents-has described the standards of normality of blood cholesterol levels in the Spanish school population. The objective of the present study was to compare mean values of cholesterol between different regions of Spain, and to compare the global mean with a pool international study. Also, the pattern of total cholesterol and cHDL by age and sex using mathematical model is described, and comparison with two international studies carried out in USA and Japan is performed. SUBJETS AND METHODS: 10,683 children aged 6 to 18 were selected from 7 different Spanish provinces (Madrid, Vizcaya, Lugo, Badajoz, Murcia, Asturias and Barcelona). Blood samples were obtained by capilar puncture (Reflotron®). RESULTS: Mean values of total cholesterol was different among provinces, and globally, were lower than the international pooled population, although the pattern observed in each population was very similar. Total cholesterol curve for Spanish boys showed a curvilinear trend that can be estimated through a cubic function that explains 89% of observed data, while for girls the best estimate was obtained through an inverse function (R2 = 0.40). cHDL for boys showed a cubic function as the best estimate (R2 = 0.90), while for girls the best estimate was obtained through a quadratic function (R2 = 0.59). CONCLUSIONS: There are important physiological variations of total cholesterol level by age and sex in children and adolescents. The pattern of cholesterol does not follow a linear model but a curvilinear one, that need to be considered in clinically assessing individual determinations of cholesterol, since highest percentiles can vary by age and sex.

Translated title of the contributionTotal cholesterol and HDL cholesterol distribution in Spanish children and adolescents: RICARDIN study
Original languageSpanish
Pages (from-to)644-649
Number of pages6
JournalMedicina Clinica
Volume115
Issue number17
DOIs
StatePublished - Nov 18 2000

Keywords

  • Children and adolescents
  • Cholesterol
  • Reference values

ASJC Scopus subject areas

  • Medicine(all)

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