TY - JOUR
T1 - Patrón de la distribución de colesterol total y cHDLen niños y adolescentes españoles
T2 - Estudio RICARDIN
AU - Cuixart, Carlos Brotons
AU - Sánchez, Rafael Gabriel
AU - Garcia, Javier Muñiz
AU - Solé, Aïda Ribera
AU - Guerrero, Serafín Málaga
AU - Sáenz Aranzubia, Pedro E.
AU - Díaz González-Blanco, M. Teresa
AU - Bayle, Marciano Sánchez
AU - Domínguez, Máximo Sandín
AU - Giménez, Vicente Bosch
AU - Garai, Esther Gorostiza
AU - Labarthe, Darwin R.
AU - Fernández-Cruz, Arturo
PY - 2000/11/18
Y1 - 2000/11/18
N2 - BACKGROUND: The RICARDIN Study -multicenter study of cardiovascular risk factors in children and adolescents-has described the standards of normality of blood cholesterol levels in the Spanish school population. The objective of the present study was to compare mean values of cholesterol between different regions of Spain, and to compare the global mean with a pool international study. Also, the pattern of total cholesterol and cHDL by age and sex using mathematical model is described, and comparison with two international studies carried out in USA and Japan is performed. SUBJETS AND METHODS: 10,683 children aged 6 to 18 were selected from 7 different Spanish provinces (Madrid, Vizcaya, Lugo, Badajoz, Murcia, Asturias and Barcelona). Blood samples were obtained by capilar puncture (Reflotron®). RESULTS: Mean values of total cholesterol was different among provinces, and globally, were lower than the international pooled population, although the pattern observed in each population was very similar. Total cholesterol curve for Spanish boys showed a curvilinear trend that can be estimated through a cubic function that explains 89% of observed data, while for girls the best estimate was obtained through an inverse function (R2 = 0.40). cHDL for boys showed a cubic function as the best estimate (R2 = 0.90), while for girls the best estimate was obtained through a quadratic function (R2 = 0.59). CONCLUSIONS: There are important physiological variations of total cholesterol level by age and sex in children and adolescents. The pattern of cholesterol does not follow a linear model but a curvilinear one, that need to be considered in clinically assessing individual determinations of cholesterol, since highest percentiles can vary by age and sex.
AB - BACKGROUND: The RICARDIN Study -multicenter study of cardiovascular risk factors in children and adolescents-has described the standards of normality of blood cholesterol levels in the Spanish school population. The objective of the present study was to compare mean values of cholesterol between different regions of Spain, and to compare the global mean with a pool international study. Also, the pattern of total cholesterol and cHDL by age and sex using mathematical model is described, and comparison with two international studies carried out in USA and Japan is performed. SUBJETS AND METHODS: 10,683 children aged 6 to 18 were selected from 7 different Spanish provinces (Madrid, Vizcaya, Lugo, Badajoz, Murcia, Asturias and Barcelona). Blood samples were obtained by capilar puncture (Reflotron®). RESULTS: Mean values of total cholesterol was different among provinces, and globally, were lower than the international pooled population, although the pattern observed in each population was very similar. Total cholesterol curve for Spanish boys showed a curvilinear trend that can be estimated through a cubic function that explains 89% of observed data, while for girls the best estimate was obtained through an inverse function (R2 = 0.40). cHDL for boys showed a cubic function as the best estimate (R2 = 0.90), while for girls the best estimate was obtained through a quadratic function (R2 = 0.59). CONCLUSIONS: There are important physiological variations of total cholesterol level by age and sex in children and adolescents. The pattern of cholesterol does not follow a linear model but a curvilinear one, that need to be considered in clinically assessing individual determinations of cholesterol, since highest percentiles can vary by age and sex.
KW - Children and adolescents
KW - Cholesterol
KW - Reference values
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U2 - 10.1016/s0025-7753(00)71650-2
DO - 10.1016/s0025-7753(00)71650-2
M3 - Article
C2 - 11141413
AN - SCOPUS:0034684548
VL - 115
SP - 644
EP - 649
JO - Medicina Clinica
JF - Medicina Clinica
SN - 0025-7753
IS - 17
ER -