Total lymphoid irradiation, anti-lymphocyte globulin and Campath 1-G for immunosuppression prior to bone marrow transplantation for aplastic anomia after repeated graft rejection

R. Or, J. Mehta*, J. Kapelushnik, M. Aker, E. Naparstek, A. Nagler, G. Cividalli, S. Slavin

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Allogeneic BMT for severe aplastic anemia is associated with a significant rate of graft rejection, especially in patients who have been previously transfused. We report a child with aplastic anemia who rejected donor marrow twice despite adequate immunosuppression as part of the conditioning therapy but engrafted successfully following combined administration of three modalities of immunosuppression: antithymocyte globulin, total lymphoid irradiation and the monoclonal antibody Cannpath-1G. Restriction fragment length polymorphism studies > 1 year after BMT show full donor hematopoiesis with no evidence of autologous recovery.

Original languageEnglish (US)
Pages (from-to)97-99
Number of pages3
JournalBone Marrow Transplantation
Volume13
Issue number1
StatePublished - Feb 23 1994

ASJC Scopus subject areas

  • Hematology
  • Transplantation

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