TY - JOUR
T1 - Total serum IgE in trimellitic anhydride-induced asthma
AU - Backman, Kenneth S.
AU - Shaughnessy, Martha A.
AU - Harris, Kathleen E.
AU - Grammer, Leslie C.
PY - 1996/4/1
Y1 - 1996/4/1
N2 - The objective of this study was to determine whether total serum IgE levels are elevated in workers with trimellitic anhydride-induced asthma as compared with anhydride-exposed workers without an occupational immunologic syndrome. Sera from 12 highly exposed workers with trimellitic anhydride- induced asthma, and from 31 similarly exposed workers without occupational immunologic disease, were assayed for total immunoglobulin E (IgE) levels by Total IgE II FAST(TM) analysis. The mean total IgE levels were 176.74 ng/mL and 34.55 ng/mL respectively. The difference between the two groups was statistically significant, but considerable overlap of IgE levels between groups was seen. In conclusion, although mean total igE levels are significantly different between TMA-exposed workers with or without occupational asthma, the significant amount of overlap and poor sensitivity of the test preclude the use of this assay in the individual evaluation of these workers.
AB - The objective of this study was to determine whether total serum IgE levels are elevated in workers with trimellitic anhydride-induced asthma as compared with anhydride-exposed workers without an occupational immunologic syndrome. Sera from 12 highly exposed workers with trimellitic anhydride- induced asthma, and from 31 similarly exposed workers without occupational immunologic disease, were assayed for total immunoglobulin E (IgE) levels by Total IgE II FAST(TM) analysis. The mean total IgE levels were 176.74 ng/mL and 34.55 ng/mL respectively. The difference between the two groups was statistically significant, but considerable overlap of IgE levels between groups was seen. In conclusion, although mean total igE levels are significantly different between TMA-exposed workers with or without occupational asthma, the significant amount of overlap and poor sensitivity of the test preclude the use of this assay in the individual evaluation of these workers.
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U2 - 10.1097/00043764-199604000-00011
DO - 10.1097/00043764-199604000-00011
M3 - Article
C2 - 8925317
AN - SCOPUS:0029923421
SN - 1076-2752
VL - 38
SP - 347
EP - 351
JO - Journal of occupational and environmental medicine
JF - Journal of occupational and environmental medicine
IS - 4
ER -
