Michellamines A-C have been prepared by total synthesis in 7 and 16 linear steps from known and commercial materials, respectively. Key steps include i) palladium(0)-mediated biaryl coupling, ii) silver oxide promoted oxidative 1-naphthol coupling to an atropisomeric mixture of cross-ring quinones (indigoids), and iii) simultaneous per-debenzylation/reductive bleaching to the central 2,2′-binaphthol.
|Original language||English (US)|
|Number of pages||4|
|State||Published - Nov 21 1994|
ASJC Scopus subject areas
- Drug Discovery
- Organic Chemistry