Total synthesis of propolisbenzofuran B

Brian T. Jones, Christopher T. Avetta, Regan J. Thomson*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

The first total synthesis of propolisbenzofuran B, a bioactive natural product isolated from honeybee propolis resin, is reported. The convergent synthesis makes use of a silicon-tether controlled oxidative ketone-ketone cross-coupling and a novel benzofuran-generating cascade reaction to deliver the core structure of the natural product from readily prepared precursors.

Original languageEnglish (US)
Pages (from-to)1794-1798
Number of pages5
JournalChemical Science
Volume5
Issue number5
DOIs
StatePublished - May 2014

ASJC Scopus subject areas

  • Chemistry(all)

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