Total synthesis of propolisbenzofuran B

Brian T. Jones; Christopher T. Avetta; Regan J. Thomson

doi:10.1039/c4sc00356j

Total synthesis of propolisbenzofuran B

Brian T. Jones, Christopher T. Avetta, Regan J. Thomson^*

^*Corresponding author for this work

Chemistry

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

The first total synthesis of propolisbenzofuran B, a bioactive natural product isolated from honeybee propolis resin, is reported. The convergent synthesis makes use of a silicon-tether controlled oxidative ketone-ketone cross-coupling and a novel benzofuran-generating cascade reaction to deliver the core structure of the natural product from readily prepared precursors.

Original language	English (US)
Pages (from-to)	1794-1798
Number of pages	5
Journal	Chemical Science
Volume	5
Issue number	5
DOIs	https://doi.org/10.1039/c4sc00356j
State	Published - May 2014

ASJC Scopus subject areas

General Chemistry

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title = "Total synthesis of propolisbenzofuran B",

abstract = "The first total synthesis of propolisbenzofuran B, a bioactive natural product isolated from honeybee propolis resin, is reported. The convergent synthesis makes use of a silicon-tether controlled oxidative ketone-ketone cross-coupling and a novel benzofuran-generating cascade reaction to deliver the core structure of the natural product from readily prepared precursors.",

author = "Jones, {Brian T.} and Avetta, {Christopher T.} and Thomson, {Regan J.}",

year = "2014",

month = may,

doi = "10.1039/c4sc00356j",

language = "English (US)",

volume = "5",

pages = "1794--1798",

journal = "Chemical Science",

issn = "2041-6520",

publisher = "Royal Society of Chemistry",

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AU - Jones, Brian T.

AU - Avetta, Christopher T.

AU - Thomson, Regan J.

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N2 - The first total synthesis of propolisbenzofuran B, a bioactive natural product isolated from honeybee propolis resin, is reported. The convergent synthesis makes use of a silicon-tether controlled oxidative ketone-ketone cross-coupling and a novel benzofuran-generating cascade reaction to deliver the core structure of the natural product from readily prepared precursors.

AB - The first total synthesis of propolisbenzofuran B, a bioactive natural product isolated from honeybee propolis resin, is reported. The convergent synthesis makes use of a silicon-tether controlled oxidative ketone-ketone cross-coupling and a novel benzofuran-generating cascade reaction to deliver the core structure of the natural product from readily prepared precursors.

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JO - Chemical Science

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Total synthesis of propolisbenzofuran B

Abstract

ASJC Scopus subject areas

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