Total synthesis of sordaricin

Lewis N. Mander*, Regan J. Thomson

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

(Matrix presented) The total synthesis of sordaricin, the diterpene aglycone of an important class of antifungal compounds, is described. Two approaches were explored, the first of which utilized a possible biogenetic intramolecular [4 + 2] cycloaddition to form the complete carbon skeleton of the target molecule. A second approach using a tandem cycloreversion/intramolecular [4 + 2] cycloaddition sequence is also detailed.

Original languageEnglish (US)
Pages (from-to)1321-1324
Number of pages4
JournalOrganic Letters
Volume5
Issue number8
DOIs
StatePublished - Apr 17 2003

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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