@article{981834d5f9264685893e3674fc74431e,
title = "Total Synthesis of Tambromycin Enabled by Indole C-H Functionalization",
abstract = "The total synthesis of tambromycin (1), a recently isolated tetrapeptide, is reported. This unusual natural product possesses a highly modified tryptophan-derived indole fragment fused to an α-methylserine-derived oxazoline ring, and a unique noncanonical amino acid residue named tambroline (11). A convergent synthesis of tambromycin was achieved by a 13-step route that leveraged recent developments in the field of C-H functionalization to prepare the complex indole fragment, as well as an efficient synthesis of tambroline that featured a diastereoselective amination of homoproline.",
author = "Miley, {Galen P.} and Rote, {Jennifer C.} and Silverman, {Richard B.} and Kelleher, {Neil L.} and Thomson, {Regan J.}",
note = "Funding Information: The research was supported by the National Institutes of Health under Award Numbers AT009143 (to N.L.K. and R.J.T.) and D012016 (Integrated Molecular Structure Education and Research Center at Northwestern University), as well as the NIH supported Chemistry of Life Processes Training Grant T32-GM105538 (to G.P.M.). J.C.R. gratefully acknowl- edges the National Science Foundation for the award of a Graduate Research Fellowship. Funding Information: The research was supported by the National Institutes of Health under Award Numbers AT009143 (to N.L.K. and R.J.T.) and D012016 (Integrated Molecular Structure Education and Research Center at Northwestern University), as well as the NIH supported Chemistry of Life Processes Training Grant T32-GM105538 (to G.P.M.). J.C.R. gratefully acknowledges the National Science Foundation for the award of a Graduate Research Fellowship. Publisher Copyright: {\textcopyright} 2018 American Chemical Society.",
year = "2018",
month = apr,
day = "20",
doi = "10.1021/acs.orglett.8b00700",
language = "English (US)",
volume = "20",
pages = "2369--2373",
journal = "Organic Letters",
issn = "1523-7060",
publisher = "American Chemical Society",
number = "8",
}