Total synthesis of the Galbulimima Alkaloid (-)-GB17

Reed T. Larson, Michael D. Clift, Regan J. Thomson*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

A tale of two Michaels: The first enantioselective total synthesis of (-)-GB17 is reported. Construction of this unique naphthoquinolizinone skeleton was achieved by two stereoselective intramolecular Michael additions, one under catalyst control and the other under substrate control.

Original languageEnglish (US)
Pages (from-to)2481-2484
Number of pages4
JournalAngewandte Chemie - International Edition
Volume51
Issue number10
DOIs
StatePublished - Mar 5 2012

Keywords

  • Galbulimima alkaloids
  • Michael addition
  • natural product synthesis
  • organocatalysis
  • substrate control

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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