Total synthesis of the Galbulimima Alkaloid (-)-GB17

Reed T. Larson; Michael D. Clift; Regan J. Thomson

doi:10.1002/anie.201108227

Total synthesis of the Galbulimima Alkaloid (-)-GB17

Reed T. Larson, Michael D. Clift, Regan J. Thomson^*

^*Corresponding author for this work

Chemistry

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

A tale of two Michaels: The first enantioselective total synthesis of (-)-GB17 is reported. Construction of this unique naphthoquinolizinone skeleton was achieved by two stereoselective intramolecular Michael additions, one under catalyst control and the other under substrate control.

Original language	English (US)
Pages (from-to)	2481-2484
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	51
Issue number	10
DOIs	https://doi.org/10.1002/anie.201108227
State	Published - Mar 5 2012

Keywords

Galbulimima alkaloids
Michael addition
natural product synthesis
organocatalysis
substrate control

ASJC Scopus subject areas

Catalysis
Chemistry(all)

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title = "Total synthesis of the Galbulimima Alkaloid (-)-GB17",

abstract = "A tale of two Michaels: The first enantioselective total synthesis of (-)-GB17 is reported. Construction of this unique naphthoquinolizinone skeleton was achieved by two stereoselective intramolecular Michael additions, one under catalyst control and the other under substrate control.",

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