Total synthesis of the Galbulimima Alkaloid (-)-GB17

Reed T. Larson; Michael D. Clift; Regan J. Thomson

doi:10.1002/anie.201108227

Total synthesis of the Galbulimima Alkaloid (-)-GB17

Reed T. Larson, Michael D. Clift, Regan J. Thomson^*

^*Corresponding author for this work

Chemistry

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

A tale of two Michaels: The first enantioselective total synthesis of (-)-GB17 is reported. Construction of this unique naphthoquinolizinone skeleton was achieved by two stereoselective intramolecular Michael additions, one under catalyst control and the other under substrate control.

Original language	English (US)
Pages (from-to)	2481-2484
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	51
Issue number	10
DOIs	https://doi.org/10.1002/anie.201108227
State	Published - Mar 5 2012

Keywords

Galbulimima alkaloids
Michael addition
natural product synthesis
organocatalysis
substrate control

ASJC Scopus subject areas

Catalysis
Chemistry(all)

Access to Document

10.1002/anie.201108227

Cite this

@article{61c63712b7fa47b4a5e5b9df5b460105,

title = "Total synthesis of the Galbulimima Alkaloid (-)-GB17",

abstract = "A tale of two Michaels: The first enantioselective total synthesis of (-)-GB17 is reported. Construction of this unique naphthoquinolizinone skeleton was achieved by two stereoselective intramolecular Michael additions, one under catalyst control and the other under substrate control.",

keywords = "Galbulimima alkaloids, Michael addition, natural product synthesis, organocatalysis, substrate control",

author = "Larson, {Reed T.} and Clift, {Michael D.} and Thomson, {Regan J.}",

year = "2012",

month = mar,

day = "5",

doi = "10.1002/anie.201108227",

language = "English (US)",

volume = "51",

pages = "2481--2484",

journal = "Angewandte Chemie - International Edition",

issn = "1433-7851",

publisher = "John Wiley and Sons Ltd",

number = "10",

}

TY - JOUR

T1 - Total synthesis of the Galbulimima Alkaloid (-)-GB17

AU - Larson, Reed T.

AU - Clift, Michael D.

AU - Thomson, Regan J.

PY - 2012/3/5

Y1 - 2012/3/5

N2 - A tale of two Michaels: The first enantioselective total synthesis of (-)-GB17 is reported. Construction of this unique naphthoquinolizinone skeleton was achieved by two stereoselective intramolecular Michael additions, one under catalyst control and the other under substrate control.

AB - A tale of two Michaels: The first enantioselective total synthesis of (-)-GB17 is reported. Construction of this unique naphthoquinolizinone skeleton was achieved by two stereoselective intramolecular Michael additions, one under catalyst control and the other under substrate control.

KW - Galbulimima alkaloids

KW - Michael addition

KW - natural product synthesis

KW - organocatalysis

KW - substrate control

UR - http://www.scopus.com/inward/record.url?scp=84857929619&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84857929619&partnerID=8YFLogxK

U2 - 10.1002/anie.201108227

DO - 10.1002/anie.201108227

M3 - Article

C2 - 22287499

AN - SCOPUS:84857929619

VL - 51

SP - 2481

EP - 2484

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

SN - 1433-7851

IS - 10

ER -

Total synthesis of the Galbulimima Alkaloid (-)-GB17

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this