Abstract
A tale of two Michaels: The first enantioselective total synthesis of (-)-GB17 is reported. Construction of this unique naphthoquinolizinone skeleton was achieved by two stereoselective intramolecular Michael additions, one under catalyst control and the other under substrate control.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2481-2484 |
| Number of pages | 4 |
| Journal | Angewandte Chemie - International Edition |
| Volume | 51 |
| Issue number | 10 |
| DOIs | |
| State | Published - Mar 5 2012 |
Funding
Keywords
- Galbulimima alkaloids
- Michael addition
- natural product synthesis
- organocatalysis
- substrate control
ASJC Scopus subject areas
- General Chemistry
- Catalysis
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Dive into the research topics of 'Total synthesis of the Galbulimima Alkaloid (-)-GB17'. Together they form a unique fingerprint.Datasets
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CCDC 854644: Experimental Crystal Structure Determination
Larson, R. T. (Creator), Clift, M. D. (Creator) & Thomson, R. J. (Creator), Cambridge Crystallographic Data Centre, 2012
DOI: 10.5517/ccxpb52, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccxpb52&sid=DataCite
Dataset
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CCDC 854646: Experimental Crystal Structure Determination
Larson, R. T. (Creator), Clift, M. D. (Creator) & Thomson, R. J. (Creator), Cambridge Crystallographic Data Centre, 2012
DOI: 10.5517/ccxpb74, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccxpb74&sid=DataCite
Dataset
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CCDC 854645: Experimental Crystal Structure Determination
Larson, R. T. (Creator), Clift, M. D. (Creator) & Thomson, R. J. (Creator), Cambridge Crystallographic Data Centre, 2012
DOI: 10.5517/ccxpb63, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccxpb63&sid=DataCite
Dataset