Toward a global and reproducible science for brain imaging in neurotrauma: the ENIGMA adult moderate/severe traumatic brain injury working group

Alexander Olsen; Talin Babikian; Erin D. Bigler; Karen Caeyenberghs; Virginia Conde; Kristen Dams-O’Connor; Ekaterina Dobryakova; Helen Genova; Jordan Grafman; Asta K. Håberg; Ingrid Heggland; Torgeir Hellstrøm; Cooper B. Hodges; Andrei Irimia; Ruchira M. Jha; Paula K. Johnson; Vassilis E. Koliatsos; Harvey Levin; Lucia M. Li; Hannah M. Lindsey; Abigail Livny; Marianne Løvstad; John Medaglia; David K. Menon; Stefania Mondello; Martin M. Monti; Virginia F.J. Newcombe; Agustin Petroni; Jennie Ponsford; David Sharp; Gershon Spitz; Lars T. Westlye; Paul M. Thompson; Emily L. Dennis; David F. Tate; Elisabeth A. Wilde; Frank G. Hillary

doi:10.1007/s11682-020-00313-7

Toward a global and reproducible science for brain imaging in neurotrauma: the ENIGMA adult moderate/severe traumatic brain injury working group

Alexander Olsen^*, Talin Babikian, Erin D. Bigler, Karen Caeyenberghs, Virginia Conde, Kristen Dams-O’Connor, Ekaterina Dobryakova, Helen Genova, Jordan Grafman, Asta K. Håberg, Ingrid Heggland, Torgeir Hellstrøm, Cooper B. Hodges, Andrei Irimia, Ruchira M. Jha, Paula K. Johnson, Vassilis E. Koliatsos, Harvey Levin, Lucia M. Li, Hannah M. LindseyAbigail Livny, Marianne Løvstad, John Medaglia, David K. Menon, Stefania Mondello, Martin M. Monti, Virginia F.J. Newcombe, Agustin Petroni, Jennie Ponsford, David Sharp, Gershon Spitz, Lars T. Westlye, Paul M. Thompson, Emily L. Dennis, David F. Tate, Elisabeth A. Wilde, Frank G. Hillary

^*Corresponding author for this work

Physical Medicine and Rehabilitation

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

The global burden of mortality and morbidity caused by traumatic brain injury (TBI) is significant, and the heterogeneity of TBI patients and the relatively small sample sizes of most current neuroimaging studies is a major challenge for scientific advances and clinical translation. The ENIGMA (Enhancing NeuroImaging Genetics through Meta-Analysis) Adult moderate/severe TBI (AMS-TBI) working group aims to be a driving force for new discoveries in AMS-TBI by providing researchers world-wide with an effective framework and platform for large-scale cross-border collaboration and data sharing. Based on the principles of transparency, rigor, reproducibility and collaboration, we will facilitate the development and dissemination of multiscale and big data analysis pipelines for harmonized analyses in AMS-TBI using structural and functional neuroimaging in combination with non-imaging biomarkers, genetics, as well as clinical and behavioral measures. Ultimately, we will offer investigators an unprecedented opportunity to test important hypotheses about recovery and morbidity in AMS-TBI by taking advantage of our robust methods for large-scale neuroimaging data analysis. In this consensus statement we outline the working group’s short-term, intermediate, and long-term goals.

Original language	English (US)
Pages (from-to)	526-554
Number of pages	29
Journal	Brain Imaging and Behavior
Volume	15
Issue number	2
DOIs	https://doi.org/10.1007/s11682-020-00313-7
State	Published - Apr 2021

Funding

PMT received partial research support from Biogen, Inc. for research unrelated to this manuscript. No other authors report potential conflicts of interest. National Health and Medical Research Council Career Development Fellowship and an ACURF Program grant by the Australian Catholic University (ACU) to Dr. Caeyenberghs. NIH/NINDS/NICHD 1U01NS086625-01 to Dr. Dams-O?Connor. K99NS096116 to Dr. Dennis. PA Health Research Grant SAP #4100077082 to Dr. Hillary. High Impact Doctoral Research Assistantship from Brigham Young University to Cooper Hodges. NIH grant R01 NS 100973 and DoD contract W81XWH-18-1-0413 to Dr. Irimia. NIH/NINDS award K23NS101036 to Dr. Jha. TBI Endpoints Development (TED) to Dr. Levin. DOD USAMRMC (PT13078) to Dr. Li. Israel Innovation Authority, ?Magneton? Grant to Dr. Livny. NIH/NIMH/NINDS through grant numbers DP5-OD-021352, R01-DC016800, R01-DC014960 to Dr. Medaglia. DKM is an Emeritus Senior Investigator of the National Institute for Health Research, UK, and is supported by the CENTER-TBI grant from the European Union. Tiny Blue Dot Foundation to Dr. Monti. Academy of Medical Science / The Health Foundation Clinician Scientist Fellowship to Dr. Newcombe. Transport Accident Commission to Dr. Ponsford. UK Dementia Research Institute to Dr. Sharp. NHMRC Early Career Fellowship to Dr. Spitz. U54 EB020403, R01 MH116147, R56 AG058854, P41 EB015922, R01 MH111671 to Dr. Thompson. The European Research Council (ERC) under the European Union?s Horizon 2020 research and innovation programme (ERC Starting Grant, Grant agreement No. 802998) and the Research Council of Norway (249795) to Dr. Westlye. National Health and Medical Research Council Career Development Fellowship and an ACURF Program grant by the Australian Catholic University (ACU) to Dr. Caeyenberghs. NIH/NINDS/NICHD 1U01NS086625-01 to Dr. Dams-O’Connor. K99NS096116 to Dr. Dennis. PA Health Research Grant SAP #4100077082 to Dr. Hillary. High Impact Doctoral Research Assistantship from Brigham Young University to Cooper Hodges. NIH grant R01 NS 100973 and DoD contract W81XWH-18-1-0413 to Dr. Irimia. NIH/NINDS award K23NS101036 to Dr. Jha. TBI Endpoints Development (TED) to Dr. Levin. DOD USAMRMC (PT13078) to Dr. Li. Israel Innovation Authority, “Magneton” Grant to Dr. Livny. NIH/NIMH/NINDS through grant numbers DP5-OD-021352, R01-DC016800, R01-DC014960 to Dr. Medaglia. DKM is an Emeritus Senior Investigator of the National Institute for Health Research, UK, and is supported by the CENTER-TBI grant from the European Union. Tiny Blue Dot Foundation to Dr. Monti. Academy of Medical Science / The Health Foundation Clinician Scientist Fellowship to Dr. Newcombe. Transport Accident Commission to Dr. Ponsford. UK Dementia Research Institute to Dr. Sharp. NHMRC Early Career Fellowship to Dr. Spitz. U54 EB020403, R01 MH116147, R56 AG058854, P41 EB015922, R01 MH111671 to Dr. Thompson. The European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (ERC Starting Grant, Grant agreement No. 802998) and the Research Council of Norway (249795) to Dr. Westlye.

Keywords

Brain injury
ENIGMA
Neurodegeneration
Open Science
Radiology
Rehabilitation

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging
Neurology
Cognitive Neuroscience
Clinical Neurology
Cellular and Molecular Neuroscience
Psychiatry and Mental health
Behavioral Neuroscience

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s11682-020-00313-7

Cite this

Olsen, A., Babikian, T., Bigler, E. D., Caeyenberghs, K., Conde, V., Dams-O’Connor, K., Dobryakova, E., Genova, H., Grafman, J., Håberg, A. K., Heggland, I., Hellstrøm, T., Hodges, C. B., Irimia, A., Jha, R. M., Johnson, P. K., Koliatsos, V. E., Levin, H., Li, L. M., ... Hillary, F. G. (2021). Toward a global and reproducible science for brain imaging in neurotrauma: the ENIGMA adult moderate/severe traumatic brain injury working group. Brain Imaging and Behavior, 15(2), 526-554. https://doi.org/10.1007/s11682-020-00313-7

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abstract = "The global burden of mortality and morbidity caused by traumatic brain injury (TBI) is significant, and the heterogeneity of TBI patients and the relatively small sample sizes of most current neuroimaging studies is a major challenge for scientific advances and clinical translation. The ENIGMA (Enhancing NeuroImaging Genetics through Meta-Analysis) Adult moderate/severe TBI (AMS-TBI) working group aims to be a driving force for new discoveries in AMS-TBI by providing researchers world-wide with an effective framework and platform for large-scale cross-border collaboration and data sharing. Based on the principles of transparency, rigor, reproducibility and collaboration, we will facilitate the development and dissemination of multiscale and big data analysis pipelines for harmonized analyses in AMS-TBI using structural and functional neuroimaging in combination with non-imaging biomarkers, genetics, as well as clinical and behavioral measures. Ultimately, we will offer investigators an unprecedented opportunity to test important hypotheses about recovery and morbidity in AMS-TBI by taking advantage of our robust methods for large-scale neuroimaging data analysis. In this consensus statement we outline the working group{\textquoteright}s short-term, intermediate, and long-term goals.",

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author = "Alexander Olsen and Talin Babikian and Bigler, {Erin D.} and Karen Caeyenberghs and Virginia Conde and Kristen Dams-O{\textquoteright}Connor and Ekaterina Dobryakova and Helen Genova and Jordan Grafman and H{\aa}berg, {Asta K.} and Ingrid Heggland and Torgeir Hellstr{\o}m and Hodges, {Cooper B.} and Andrei Irimia and Jha, {Ruchira M.} and Johnson, {Paula K.} and Koliatsos, {Vassilis E.} and Harvey Levin and Li, {Lucia M.} and Lindsey, {Hannah M.} and Abigail Livny and Marianne L{\o}vstad and John Medaglia and Menon, {David K.} and Stefania Mondello and Monti, {Martin M.} and Newcombe, {Virginia F.J.} and Agustin Petroni and Jennie Ponsford and David Sharp and Gershon Spitz and Westlye, {Lars T.} and Thompson, {Paul M.} and Dennis, {Emily L.} and Tate, {David F.} and Wilde, {Elisabeth A.} and Hillary, {Frank G.}",

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year = "2021",

month = apr,

doi = "10.1007/s11682-020-00313-7",

language = "English (US)",

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Olsen, A, Babikian, T, Bigler, ED, Caeyenberghs, K, Conde, V, Dams-O’Connor, K, Dobryakova, E, Genova, H, Grafman, J, Håberg, AK, Heggland, I, Hellstrøm, T, Hodges, CB, Irimia, A, Jha, RM, Johnson, PK, Koliatsos, VE, Levin, H, Li, LM, Lindsey, HM, Livny, A, Løvstad, M, Medaglia, J, Menon, DK, Mondello, S, Monti, MM, Newcombe, VFJ, Petroni, A, Ponsford, J, Sharp, D, Spitz, G, Westlye, LT, Thompson, PM, Dennis, EL, Tate, DF, Wilde, EA & Hillary, FG 2021, 'Toward a global and reproducible science for brain imaging in neurotrauma: the ENIGMA adult moderate/severe traumatic brain injury working group', Brain Imaging and Behavior, vol. 15, no. 2, pp. 526-554. https://doi.org/10.1007/s11682-020-00313-7

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AU - Olsen, Alexander

AU - Babikian, Talin

AU - Bigler, Erin D.

AU - Caeyenberghs, Karen

AU - Conde, Virginia

AU - Dams-O’Connor, Kristen

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AU - Koliatsos, Vassilis E.

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AU - Li, Lucia M.

AU - Lindsey, Hannah M.

AU - Livny, Abigail

AU - Løvstad, Marianne

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AU - Sharp, David

AU - Spitz, Gershon

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AU - Hillary, Frank G.

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AB - The global burden of mortality and morbidity caused by traumatic brain injury (TBI) is significant, and the heterogeneity of TBI patients and the relatively small sample sizes of most current neuroimaging studies is a major challenge for scientific advances and clinical translation. The ENIGMA (Enhancing NeuroImaging Genetics through Meta-Analysis) Adult moderate/severe TBI (AMS-TBI) working group aims to be a driving force for new discoveries in AMS-TBI by providing researchers world-wide with an effective framework and platform for large-scale cross-border collaboration and data sharing. Based on the principles of transparency, rigor, reproducibility and collaboration, we will facilitate the development and dissemination of multiscale and big data analysis pipelines for harmonized analyses in AMS-TBI using structural and functional neuroimaging in combination with non-imaging biomarkers, genetics, as well as clinical and behavioral measures. Ultimately, we will offer investigators an unprecedented opportunity to test important hypotheses about recovery and morbidity in AMS-TBI by taking advantage of our robust methods for large-scale neuroimaging data analysis. In this consensus statement we outline the working group’s short-term, intermediate, and long-term goals.

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KW - Neurodegeneration

KW - Open Science

KW - Radiology

KW - Rehabilitation

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Toward a global and reproducible science for brain imaging in neurotrauma: the ENIGMA adult moderate/severe traumatic brain injury working group

Abstract

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ASJC Scopus subject areas

UN SDGs

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